Interleukin-1 receptor–like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood Olga E.M. Savenije, MD, Marjan Kerkhof,

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Interleukin-1 receptor–like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood Olga E.M. Savenije, MD, Marjan Kerkhof, MD, PhD, Naomi E. Reijmerink, MD, PhD, Bert Brunekreef, PhD, Johan C. de Jongste, MD, PhD, Henriëtte A. Smit, PhD, Alet H. Wijga, PhD, Dirkje S. Postma, MD, PhD, Gerard H. Koppelman, MD, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 3, Pages 750-756.e5 (March 2011) DOI: 10.1016/j.jaci.2010.12.014 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Recruitment scheme of the PIAMA study. Journal of Allergy and Clinical Immunology 2011 127, 750-756.e5DOI: (10.1016/j.jaci.2010.12.014) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Schematic overview of IL1RL1 region, splice variants (IL1RL1-a and IL1RL1-b), and IL1RL1 SNPs with their LD structure within PIAMA. The upper line describes the nucleotide sequence. The second and third lines describe splice variant IL1RL1-a and IL1RL1-b, where blocks are exons and lines are introns. The table shows the LD between the SNPs in the PIAMA cohort with the thick lines representing blocks of high LD (D' 99% CI ≥0.70-0.99 for 99% of SNP pairs). Journal of Allergy and Clinical Immunology 2011 127, 750-756.e5DOI: (10.1016/j.jaci.2010.12.014) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association of rs11685480 and rs1041973 with IL1RL1-a levels at ages 4 and 8 years (A and B) and eosinophils count (C and D). This figure shows the mean IL1RL1-a level with 95% CI of rs11685480 (A) and rs1041973 (B) at ages 4 and 8 years and the mean eosinophil counts for these SNPs (C and D). Frequency of genotypes is reported under the x-axis. ∗Significant associations after correction for multiple testing. Journal of Allergy and Clinical Immunology 2011 127, 750-756.e5DOI: (10.1016/j.jaci.2010.12.014) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

LD plot of IL1RL1, IL18R1, and IL18RAP SNPs LD plot of IL1RL1, IL18R1, and IL18RAP SNPs. Pairwise LD (r2) among SNPs of IL1RL1, IL18R1, and IL18RAP with marked independent significantly associated SNPs with IL1RL1-a serum levels (red continuous circles) and eosinophil counts (dotted green circles). Journal of Allergy and Clinical Immunology 2011 127, 750-756.e5DOI: (10.1016/j.jaci.2010.12.014) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions