One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

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One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. Normalized, log 2–transformed expression ratios of SAM-identified differentially regulated genes between GBMs (grade IV) and lower-grade astrocytomas (grades II and III) were subjected to one-way hierarchical clustering using the TMEV software. A dual-color code was used, with red and green indicating upregulation and downregulation, respectively, in a particular glioma sample compared with normal brain tissue. Subclusters A and B represent genes that are upregulated and downregulated respectively in GBMs compared with lower-grade astrocytoma (grades II and III). Peddagangannagari Sreekanthreddy et al. Cancer Epidemiol Biomarkers Prev 2010;19:1409-1422 ©2010 by American Association for Cancer Research