Survival of children with sickle cell disease

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Presentation transcript:

Survival of children with sickle cell disease by Charles T. Quinn, Zora R. Rogers, and George R. Buchanan Blood Volume 103(11):4023-4027 June 1, 2004 ©2004 by American Society of Hematology

Survival of children with SS and Sβ°. Survival of children with SS and Sβ°. Shown are overall survival (A), SCD-related mortality (B), and stroke-free survival (C). Numbers above the x-axes indicate the number of subjects remaining at risk at a particular age. Dotted lines delimit the 95% CIs. (D) Overall survival curves for the Jamaican cohort study of SCD (SS only), the CSSCD infant cohort (SS only), and the Dallas Newborn Cohort (SS and Sβ°). Vertical bars indicate upper or lower boundaries of the 95% CIs (one direction omitted for clarity). The survival curve for the CSSCD infant cohort was published for approximately 4 years of observation only.11 The Jamaican cohort was divided into thirds based on date of birth. Subjects in the first third (1973-1975) did not routinely receive prophylactic PCN, whereas subjects in the middle (1975-1979) and last (1979-1981) thirds did receive PCN. Survival curves are shown only for the first and last third of the Jamaican cohort. Charles T. Quinn et al. Blood 2004;103:4023-4027 ©2004 by American Society of Hematology