Fcγ-receptor 3B (FCGR3B) copy number variations in patients with eosinophilic granulomatosis with polyangiitis Davide Martorana, PhD, Francesco Bonatti,

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Presentation transcript:

Fcγ-receptor 3B (FCGR3B) copy number variations in patients with eosinophilic granulomatosis with polyangiitis Davide Martorana, PhD, Francesco Bonatti, PhD, Federico Alberici, MD, Andrea Gioffredi, MD, Michele Reina, PhD, Maria L. Urban, MD, Federica Maritati, MD, Alessia Adorni, PhD, Antonella Radice, PhD, Silvia Pizzolato, MD, Gina Gregorini, MD, Guido Jeannin, MD, Giuseppe Guida, MD, PhD, Monica Boita, PhD, Alberto Pesci, MD, Gabriella Moroni, MD, Tauro M. Neri, MD, Renato A. Sinico, MD, Augusto Vaglio, MD, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 5, Pages 1597-1599.e8 (May 2016) DOI: 10.1016/j.jaci.2015.09.053 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Three representative examples of amplification efficiency plots for CN assays (FCGR3B target and RNaseP reference) calculated with input DNA concentrations of 7 different dilutions (0.625-40 ng DNA) per reaction. Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Histograms of FCGR3B CNV analysis with the CopyCaller v2.0 program. The software displays 1 bar for each analyzed sample. The y-axis displays the CN for each sample, and the x-axis displays the samples. For example, sample A_01 has 1 copy of FCGR3B, sample A_03 has 2 copies of FCGR3B, and sample A_04 has 3 copies of FCGR3B. Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Distribution of FCGR3B CNs of 1 versus 2 or greater in patients with EGPA and healthy control subjects. Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Distribution of each CN of the FCGR3B gene in patients with EGPA and healthy control subjects. Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Eosinophil counts in patients with EGPA with FCGR3B CNVs of 1 versus 2 or greater (P = .77). Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 C-reactive protein (CRP) levels in patients with EGPA with FCGR3B CNVs of 1 versus 2 or greater (P = .46). Journal of Allergy and Clinical Immunology 2016 137, 1597-1599.e8DOI: (10.1016/j.jaci.2015.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions