Fig. 1 Schematic of our study model.

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Fig. 1 Schematic of our study model. Schematic of our study model. iPSC, induced pluripotent stem cells; NPC, neural precursor cells; N, neurons; APOE4, apolipoprotein E isoform 4; PSEN1, presenilin 1; PSEN2, presenilin 2; WT, wild type; MAB-seq, methylase-assisted bisulfite sequencing; OXBS-seq, oxidative bisulfite sequencing; DMRs, differentially methylated regions; DHMRs, differentially hydroxymethylated regions; DFCRs, differentially formyl/carboxylated regions. Irfete S. Fetahu et al. Sci Adv 2019;5:eaaw2880 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).