Fig. 4 Conformational dynamics of the activation loop of PKA-CWT and PKA-CL205R upon binding substrate. Conformational dynamics of the activation loop.

Slides:

Advertisements

Similar presentations

Fig. 4 Ballistic simulation of BP FETs.

Advertisements

Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 CL-DMD modeling of FKBP.

Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.

Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.

Fig. 3 Vibrational spectra of human bones from the Copper Age (Scoglietto cave, Italy). Vibrational spectra of human bones from the Copper Age (Scoglietto.

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

HT synthesis of boronic acids using the building block approach

Fig. 6 Comparison of properties of water models.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.

Fig. 4 Structural details of tRNA binding to Elp123.

Fig. 2 The glucose binding and charge-switch study.

Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 2 Stratigraphic profile of the Area 15 excavation block showing the diagnostic cultural materials and components alongside the stratigraphic sequence.

Fig. 4 Steady-state difference SAXS, modeling of hydration layer, FFW flexibility in MD simulations, and active-site hydrogen bonding network. Steady-state.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 Structural photocycle for DmCry.

FTIR-ATR spectra of Neolithic faunal bones (Mora Cavorso cave, Italy)

Fig. 1 Distribution of total and fake news shares.

Spin diffusion buildup from bound water to amide protons in NaK2K

Fig. 3 Photon number statistics resulting from Fock state |l, S − l〉 interference. Photon number statistics resulting from Fock state |l, S − l〉 interference.

Fig. 2 2D QWs of different propagation lengths.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 2 Assignment of back-exchanged deuterated NaK2K.

Fig. 1 Boronic acid–rich dendrimer with robust efficiency in cytosolic protein delivery. Boronic acid–rich dendrimer with robust efficiency in cytosolic.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 Praying Prophet by Lorenzo Monaco: Mapping lake pigments and associated substrate. Praying Prophet by Lorenzo Monaco: Mapping lake pigments and.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

Fig. 2 Magnetic properties of FGT/Pt bilayer.

Specificity profiling, activity in human plasma, and x-ray structure

Fig. 4 Visualization of complex loop motions by 1-μs MD trajectories.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 4 SPICE simulation of stochasticity.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 1 Gradients of species richness and predicted turnover through extinction and redistribution. Gradients of species richness and predicted turnover.

Fig. 1 Architecture of PKA-C and locations of the Cushing’s syndrome mutations. Architecture of PKA-C and locations of the Cushing’s syndrome mutations.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 1 Location of the Jirzankal Cemetery.

MD simulation on the nonfouling mechanism of PTMAO at molecular level

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 3 Maximal energy intake.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Effects of experimental warming on nematode communities across the gradient of plant species richness. Effects of experimental warming on nematode.

Fig. 3 Electronic conductivity studies.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 1 Chemical structures of the bioconjugates.

Fig. 3 Archaeological site numbers in northern China, longitudinal spread of millet in eastern Asia, and probability distribution of available millet datings.

Fig. 2 Latitudinal changes in the sea-ice drivers.

Fig. 5 Density plots showing the relationship between growth responses to extreme events and site-level mean precipitation from all sites (N = 1314). Density.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Presentation transcript:

Fig. 4 Conformational dynamics of the activation loop of PKA-CWT and PKA-CL205R upon binding substrate. Conformational dynamics of the activation loop of PKA-CWT and PKA-CL205R upon binding substrate. (A) Distinct opening-closing motions of the Gly-rich loop highlighting the hindered conformation that occludes the entering of ATP in PKA-CL205R. (B) Probability density describing the conformation of the activation loop in response to different substrates and pseudo-substrates. (C) [1H, 15N]-TROSY-HSQC spectra showing the backbone amide chemical shift changes of the W196 indole amide (located on the activation loop) in response to binding PKI or VPS36. (D) X-ray structure of PKA-CWT (gray) (PDB ID: 1ATP) with the overlay PKA-CL205R in complex with PKI (light blue) (PDB ID: 4WB6) describing the architecture of the peptide binding site and activation loop flip. (E) X-ray structure of PKA-CWT (gray) (PDB ID: 1ATP) with the overlay PKA-CL205R in complex with VPS36 (light blue) (MD simulations) describing the architecture of the peptide binding site and activation loop flip. Caitlin Walker et al. Sci Adv 2019;5:eaaw9298 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).