Connecting with an Old Partner in a New Way

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Presentation transcript:

Connecting with an Old Partner in a New Way John E. Burke, Roger L. Williams Cancer Cell Volume 23, Issue 5, Pages 559-561 (May 2013) DOI: 10.1016/j.ccr.2013.04.023 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Non-Canonical Activation of Oncogenic Mutants of PI3Kα by IRS1 (A) Crystal structure of the nSH2 and iSH2 of p85 (blue) with p110α (gray) (Mandelker et al., 2009), illustrating oncogenic mutants that induced (red) or did not induce (yellow) IRS1 binding. (B) Domain architecture of p110α and locations of mutants tested by Hao et al. (2013) along with the location of inhibitory contacts between the p110α and p85 subunits. (C) Non-canonical activation of PI3Kα by IRS1 leads to increased downstream signaling and enhanced tumor volume. Cancer Cell 2013 23, 559-561DOI: (10.1016/j.ccr.2013.04.023) Copyright © 2013 Elsevier Inc. Terms and Conditions