ROR1 expression is inversely correlated to Wnt5A/ROR2.

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ROR1 expression is inversely correlated to Wnt5A/ROR2. ROR1 expression is inversely correlated to Wnt5A/ROR2. A, gene expression of ROR1 in multiple microarray databases of melanoma cell lines divided into a more proliferative, less metastatic cohort (cohort A) versus a highly metastatic cohort (cohort C; P < 0.001). B, qRT-PCR of ROR1 mRNA levels in a panel of poorly invasive compared with highly invasive cell lines (P < 0.01; P < 0.001). C, qRT-PCR of ROR2 mRNA levels in a panel of poorly invasive compared with highly invasive cell lines (P < 0.01; P < 0.001). D, Western blot analysis of ROR1 and ROR2 expression in poorly invasive and highly invasive cell lines. E, immunofluorescent analysis of ROR1 (green), Wnt5A (red), and ROR2 (green) protein expression in organotypic 3D reconstruct models of melanocytes and melanoma cells in RGP (RGP-WM35), VGP (VGP-WM793), and metastatic (MET-1205Lu) stages. Hematoxylin and eosin (H&E) staining of organotypic 3D reconstruct models of melanocytes and melanoma cells in RGP, VGP, and MET stages is shown on the right. RGP, radial growth phase; VGP, vertical growth phase; DAPI, 4,6-diamidino-2-phenylindole. Michael P. O'Connell et al. Cancer Discovery 2013;3:1378-1393 ©2013 by American Association for Cancer Research