Correlation of HIV-1 replication fitness, as measured by the Monogram Biosciences RC assay, with baseline CD4+ T-cell count (a) and baseline plasma HIV-1.

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Correlation of HIV-1 replication fitness, as measured by the Monogram Biosciences RC assay, with baseline CD4+ T-cell count (a) and baseline plasma HIV-1 RNA concentration (b) in a cohort of chronically infected children and adults with hemophilia. Correlation of HIV-1 replication fitness, as measured by the Monogram Biosciences RC assay, with baseline CD4+ T-cell count (a) and baseline plasma HIV-1 RNA concentration (b) in a cohort of chronically infected children and adults with hemophilia. (a) y axis, square root-transformed baseline CD4+ T-cell count; x axis, RC expressed as a percentage of the wild-type reference strain. The solid line indicates fit of data by linear regression (r2 = −0.199; P = 0.02). (b) y axis, log10-transformed baseline plasma HIV-1 RNA concentration; x axis, RC expressed as a percentage of the wild-type reference strain. The solid line indicates the fit of data by linear regression (r2 = +0.189; P = 0.03). (Reprinted from reference 37 with permission of the publisher.)‏ Carrie Dykes, and Lisa M. Demeter Clin. Microbiol. Rev. 2007; doi:10.1128/CMR.00017-07