The combination of trastuzumab and SU11274 abrogate Akt phosphorylation. The combination of trastuzumab and SU11274 abrogate Akt phosphorylation. Serum-starved.

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The combination of trastuzumab and SU11274 abrogate Akt phosphorylation. The combination of trastuzumab and SU11274 abrogate Akt phosphorylation. Serum-starved BT474 cells (A) and SKBR3 cells (B) were treated with 1 μmol/L SU11274 in the presence or absence of 21 μg/mL trastuzumab. Whole-cell lysates of BT474 and SKBR3 cells were collected after treatment and analyzed for phosphorylated Akt, phosphorylated Erk, and actin content by SDS-PAGE followed by Western blot. David L. Shattuck et al. Cancer Res 2008;68:1471-1477 ©2008 by American Association for Cancer Research