p110δ activity is important for autoantibody responses.

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p110δ activity is important for autoantibody responses. p110δ activity is important for autoantibody responses. A and B, Serum samples (1/100 dilution) from unimmunized wild-type (WT) and p110δD910A KI mice were assayed for IgM and IgG Abs that recognize Ags present in mouse heart extract (A) or IgM Abs against cardiac myosin (B). Values for the mean (horizontal bars) and for individual mice (dots) are shown. C, Purified MZ B cells were cultured for 48 h with 1 μM CpG DNA in the presence of 2 μM IC87114 or DMSO before culture supernatants were assayed by ELISA for IgM Abs to cardiac myosin. D, Purified peritoneal B-1 cells were cultured for 72 h with medium alone, 25 μg/ml anti-IgM, 1 μM CpG DNA, 10 μg/ml LPS, or 1 μg/ml purified lipid A in the presence of DMSO or 2 μM IC87114. Culture supernatants were assayed for IgM Abs specific for cardiac myosin. Each bar is the mean ± SD for triplicate samples. Unstim, Unstimulated. Caylib A. Durand et al. J Immunol 2009;183:5673-5684 Copyright © 2009 by The American Association of Immunologists, Inc.