Scatter plot of serum OPN levels and its correlation with patient survival. Scatter plot of serum OPN levels and its correlation with patient survival.

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Scatter plot of serum OPN levels and its correlation with patient survival. Scatter plot of serum OPN levels and its correlation with patient survival. A, serum levels of OPN (ng/mL) in normal controls (n = 22), DAs (n = 12), AAs (n = 36), and GBMs (n = 78). The horizontal line in each group designates the mean value. B, total serum protein (2.5 μL) from normal healthy controls and GBM patients was subjected to Western blot analysis for OPN. C, Kaplan-Meier survival estimates for 30 GBM patients are calculated for their serum OPN levels. Survival curves for the groups positive and negative for OPN in univariate analysis are shown. Cases that were low for serum OPN levels (≤20 ng/mL; black line; n = 19) had a better survival than the cases that were high for serum OPN levels (>20 ng/mL; gray line; n = 11; P = 0.0001). Peddagangannagari Sreekanthreddy et al. Cancer Epidemiol Biomarkers Prev 2010;19:1409-1422 ©2010 by American Association for Cancer Research