Tipping the Energy Balance toward Longevity

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Presentation transcript:

Tipping the Energy Balance toward Longevity William Mair Cell Metabolism Volume 17, Issue 1, Pages 5-6 (January 2013) DOI: 10.1016/j.cmet.2012.11.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Tipping the Energy Balance: Mutations in AMP Biosynthesis Pathways Increase the AMP::ATP Ratio to Increase Longevity (A) Under normal conditions, de novo and salvage pathways are active, synthesizing AMP, which is converted to ATP, resulting in a low AMP::ATP ratio and normal life span. (B) Mutations in genes involved in AMP biosynthesis swing the energy balance to mimic a low-energy state. AMP::ATP ratios are increased, promoting longevity via activation of AMPK. Cell Metabolism 2013 17, 5-6DOI: (10.1016/j.cmet.2012.11.011) Copyright © 2013 Elsevier Inc. Terms and Conditions