PK profile of OTL78. PK profile of OTL78. A, Representative time-dependent whole-body fluorescence images over white light images of a mouse bearing 22Rv1.

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PK profile of OTL78. PK profile of OTL78. A, Representative time-dependent whole-body fluorescence images over white light images of a mouse bearing 22Rv1 tumor after injecting 10 nmol/L of OTL78 and image with IVIS imager at different time intervals (n = 5 mice/group). B, Clearance of OTL78 from tumor, kidney, and skin from time-dependent biodistribution analysis. C, Determination of half-life of OTL78 by time-dependent serum analysis. Error bar, SD (n = 3 mice/group). K, kidneys. Sumith A. Kularatne et al. Clin Cancer Res 2019;25:177-187 ©2019 by American Association for Cancer Research