Whole-mount analysis of tumor induced lymphatic sprouting by confocal microscopy. Whole-mount analysis of tumor induced lymphatic sprouting by confocal.

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Whole-mount analysis of tumor induced lymphatic sprouting by confocal microscopy. Whole-mount analysis of tumor induced lymphatic sprouting by confocal microscopy. A and B, whole-mount staining for LYVE-1 of ears implanted with EGFP-expressing tumor cells. Note extensive lymphatic sprouting (A, arrowheads; day 4), and lymphatic vessels growing around a tumor cell mass (B; day 12). C and D, tumor induction of lymphatic sprouting was inhibited in mice treated with AdVEGFR-3-Ig (C, lymphatics alone; D, overlay of lymphatics with tumor cells). E and F, FITC-dextran microlymphography of the lymphatic vessels surrounding tumors implanted in the s.c. tissues of ears from mice treated with AdLacZ (E) or AdVEGFR-3-Ig (F). Dotted lines, tumor position; arrows, FITC-dextran injection sites. Bar: 100 μm (A), 80 μm (B), 40 μm (C and D), and 800 μm (E and F). Yulong He et al. Cancer Res 2005;65:4739-4746 ©2005 by American Association for Cancer Research