Total drug dose by device and condition while delivering 1 mL of ribavirin (5 min for the small-particle aerosol generator [SPAG] or 2 min for the vibrating.

Slides:

Advertisements

Similar presentations

Effect of nasal positive expiratory pressure (PEP) on 6-min walk test (6MWT) distance and pre- to post-exercise increase in lung volumes in each individual.

Advertisements

Effect of gas density on aerosol delivery from a pressurized metered-dose inhaler (pMDI) and jet nebulizer. A. Albuterol was administered via a pMDI and.

The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.

Chapter 3 Administration of Aerosolized Agents

Trigger pressure-time product (PTP) with zero pressure support, with no leak, medium leak, and large leak. Trigger pressure-time product (PTP) with zero.

Spearman rank correlation between absolute humidity and the patient's core temperature with the Humid-Heat device. Spearman rank correlation between absolute.

Matrix used to calculate the kappa statistic.

Trigger delays and leaks.

Model of relationship between ventilation and perfusion.

The Spectrum mask incorporates the leak port into the circuit, whereas the Mirage mask incorporates the leak port into the mask. The Spectrum mask incorporates.

Picture of bubble PEP devices.

Flow chart of pressure support test and spontaneous breathing trial (SBT). Flow chart of pressure support test and spontaneous breathing trial (SBT). The.

Respirable mass, expressed as percent of nominal dose.

The high flow nasal cannula (HFNC) system incorporated an air/O2 blender with a flow meter and a heated humidifier. The high flow nasal cannula (HFNC)

A: Pressure (green) and volume (black)/time curve in airway pressure release ventilation (APRV). A: Pressure (green) and volume (black)/time curve in airway.

The third breath has a negative deflection (ie, below PEEP) at the end of the mechanical breath (arrow A) associated with a flow increase (arrow B), indicating.

Simulated screenshot of flow starvation in volume control continuous mandatory ventilation. Simulated screenshot of flow starvation in volume control continuous.

Indications for ventilation in adults

The peak flows (60 L/min) and flow patterns are the same for all the breaths. The peak flows (60 L/min) and flow patterns are the same for all the breaths.

Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value, Area Under the Curve, and 95% CIs for the 0, 10, 25, 50, and 100 SatSeconds.

Two methacholine dosing schemes.

A: Machine-triggered intermittent mandatory ventilation (IMV) with inadequate patient triggering of mandatory breaths. A: Machine-triggered intermittent.

Trigger and synchronization windows.

Recommendations from the Pre-hospital Trauma Life Support (PHTLS) manual for FIO2 delivery, based on breathing frequency and FIO2 capabilities of devices.

Ineffective efforts and operation of apnea ventilation during pressure control continuous spontaneous ventilation (PC-CSV). Ineffective efforts and operation.

Example of Aerogen Solo Nebulizer before use with a fill volume of 3 mL normal saline (arrow 1) (A); the same nebulizer after random premature cessation.

Negative pressures calculated with the Rosen and Hillard formula

We connected the supplemental oxygen supply at 3 places: near the ventilator, near the exhalation valve, and on the nasal mask port. We connected the supplemental.

Changes in PaO2/FIO2 (A) and PaCO2 (B).

Carbon monoxide (CO) delivery system used in animal models and Phase 1 clinical trials. Carbon monoxide (CO) delivery system used in animal models and.

Schematic representation of the proposed definition of prolonged mechanical ventilation (PMV) in neonates and children. Schematic representation of the.

Change in mean pulmonary arterial pressure after a 5-min inhalation of the Rho kinase inhibitor Y in rats with hypoxic pulmonary hypertension, with.

Electrical impedance tomographic (EIT) images are created using a series of electrodes placed across the chest, each of which send and receive electrical.

Study protocol. Study protocol. Subjects with hemodynamic, respiratory, and neurologic stability and positive predictive index were randomized to 3 groups.

Comparison of alkaline glycine to normal saline inhalation (study 1).

Intra-device comparison of albuterol captured at the end of the endotracheal tube (lung dose). Intra-device comparison of albuterol captured at the end.

Inter-device comparison

A novel multi-channeled neonatal patient Y-piece device (AFECTAIR) developed as part of an aerosolized lung surfactant administration system to be used.

Change in trigger delay during invasive (A) and noninvasive ventilation (B) with variable leak. Change in trigger delay during invasive (A) and noninvasive.

Venn diagram illustrating how the mode taxonomy can be viewed in terms of discriminating features and defining features. Venn diagram illustrating how.

A: Pressure ulcer on the left cheek of a patient after 1 week of prone positioning using a commercially available endotracheal tube (ETT) holder. A: Pressure.

Kaplan-Meier curve for the probability of noninvasive ventilation (NIV) failure relative to continuous use of NIV and stratified for Acute Physiology and.

Experimental setup of particle distribution using the 8-stage Andersen cascade impactor and in vitro module using an absolute filter. Experimental setup.

The cause of asynchrony during volume-targeted ventilation and total asynchrony index. The cause of asynchrony during volume-targeted ventilation and total.

SpO2 at baseline, pre- and post-intubation.

Graphical representation of the locations where spontaneous breaths may occur during the airway pressure (Paw) release ventilation ventilatory cycle. Graphical.

Mean inspiratory work of breathing during assisted breaths and spontaneous breaths across the spectrum of ventilatory support continuous mandatory ventilation.

Calculated negative pressure developed in the lung plotted against the outside diameter of the suction catheter to the inside diameter of the airway. Calculated.

Survival of subjects listed for heart transplantation with and without spirometry. Survival of subjects listed for heart transplantation with and without.

Schematic of mechanisms behind the better recruitment of alveoli with spontaneous breathing. Schematic of mechanisms behind the better recruitment of alveoli.

Bland-Altman analysis of the end-tidal carbon dioxide concentration (PETCO2) during resting (A), with mouth closed (B), and during deep breathing (C) while.

Components of a patient-triggered mechanical breath.

Pulmonary vascular resistance (PVR; dyn/s/cm) at baseline and after exposure to inhaled nitric oxide (INO; 20 ppm) for 10 min, inhaled epoprostenol (EPO;

Indications for ventilation in children and adolescents

Ventilation protocol. Ventilation protocol. The PEEP group raised peak inspiratory pressure (PIP) through 5-cm H2O PEEP increments every 2 min while keeping.

Tidal volume (VT) error (% difference between set and actual values) was determined for each ventilator at VT of 300, 500, and 700 mL. Tidal volume (VT)

A: Work of breathing before and after nebulized terbutaline delivered via standard nebulization method versus delivered during continuous positive airway.

Sequence plot visualizing the development of symptom frequency for the cohort at the individual level between 2006 and Sequence plot visualizing.

The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.

Number of ventilator starts (including both noninvasive ventilation [NIV] and invasive mechanical ventilation subjects) based on age and etiology of ARF.

Representative tidal volume (VT) and breathing frequency (f) patterns of subjects with COPD and normal subjects during cardiopulmonary exercise testing.

Plot of the surface tension (γ) and area.

Progression of spontaneous breathing trials administered during inspiratory muscle strength training study interventions. Progression of spontaneous breathing.

Delivery efficiency with different devices, ventilator positions, and ventilator settings. Delivery efficiency with different devices, ventilator positions,

Efficiency of aerosol bronchodilator delivery during continuous high-flow system at different CPAP and flow levels. Efficiency of aerosol bronchodilator.

Average drug doses in the peripheral lung, central lung, and extrathoracic airway; residual drug left in the device; and residual drug that was exhaled.

Basic setup for high-flow nasal cannula oxygen delivery.

Percent of extremely-low-birth-weight (ELBW) babies alive and off mechanical ventilation at 7 days, and median days on mechanical ventilation for ELBW.

Minute-by-minute means of breathing variables during the spontaneous breathing trial for the groups of subjects with trial success (n = 32) and failure.

Setup of the BiPAP Synchrony with an inspiratory filter and single-limb passive circuit, with the filter placed over the fixed leak to collect aerosol.

Presentation transcript:

Total drug dose by device and condition while delivering 1 mL of ribavirin (5 min for the small-particle aerosol generator [SPAG] or 2 min for the vibrating mesh micropump [VMM]). Total drug dose by device and condition while delivering 1 mL of ribavirin (5 min for the small-particle aerosol generator [SPAG] or 2 min for the vibrating mesh micropump [VMM]). Shown are the inhaled dose during spontaneous breathing and inhaled dose during mechanical ventilation. Table 2 provides additional details and percentage of drug delivery. Results before nebulization were used to calculate the percentage of inhaled dose. Brian K Walsh et al. Respir Care 2016;61:577-585 (c) 2012 by Daedalus Enterprises, Inc.