The long tail of mutational hotspots in cancer.

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Date of download: 6/1/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association of Type and Location of BRCA1 and BRCA2.

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The long tail of mutational hotspots in cancer. The long tail of mutational hotspots in cancer. A, The frequency distribution of genes containing one or more single-codon hotspots (top, dark blue) and in-frame indel hotspots (light blue). At bottom, the count of single-codon and in-frame indel hotspots in the same genes. B, Shown is the statistical significance of mutational hotspots inferred from the analysis of the full cohort (pan-cancer, y axis) and the most significant individual cancer type (x axis). A subset of hotspots are annotated (circled in black) and include mutations significant in both analyses (top right), those significant only when combining all cancer types and data (leftmost), and those significant only within a given cancer type (bottom). C, The proportion of hotspots that were significant only in individual organ types, only in the pan-cancer analysis, or both. Matthew T. Chang et al. Cancer Discov 2018;8:174-183 ©2018 by American Association for Cancer Research