Increased INaP in CA1 pyramidal neurons from pilocarpine-treated rats.

Slides:

Advertisements

Similar presentations

Timing and Specificity of Feed-Forward Inhibition within the LGN

Advertisements

Complementary Tuning of Na+ and K+ Channel Gating Underlies Fast and Energy- Efficient Action Potentials in GABAergic Interneuron Axons Hua Hu, Fabian.

Volume 93, Issue 2, Pages (January 2017)

Sodium Entry during Action Potentials of Mammalian Neurons: Incomplete Inactivation and Reduced Metabolic Efficiency in Fast-Spiking Neurons Brett C.

Endocannabinoids Control the Induction of Cerebellar LTD

Dynamic Control of Presynaptic Ca2+ Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons Jörg R.P. Geiger, Peter Jonas Neuron

Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid- Dependent Lipid Signaling Stephanie C. Gantz, Bruce P. Bean Neuron Volume.

Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice Indira M Raman, Leslie K Sprunger, Miriam.

Activation of a chondrocyte volume-sensitive Cl− conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament.

Chenguang Zheng, Kevin Wood Bieri, Yi-Tse Hsiao, Laura Lee Colgin

Firing Rate Homeostasis in Visual Cortex of Freely Behaving Rodents

Volume 52, Issue 5, Pages (December 2006)

Klaus Bielefeldt, Noriyuki Ozaki, Gerald F. Gebhart Gastroenterology

K. Bielefeldt, N. Ozaki, G.F. Gebhart Gastroenterology

Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity Melanie A Woodin, Karunesh.

Volume 16, Issue 1, Pages (January 1996)

Volume 75, Issue 6, Pages (September 2012)

Modeling of an isolated rhythm-generating population.

Active Currents Regulate Sensitivity and Dynamic Range in C

Volume 93, Issue 2, Pages (January 2017)

Volume 23, Issue 9, Pages (May 2018)

Volume 90, Issue 3, Pages (May 2016)

Rebecca S. Jones, Reed C. Carroll, Scott Nawy Neuron

Arc expression increases H4K12Ac levels.

MN-enriched miRNAs are depleted temporally in ALS rodent model and human patient spinal cord. MN-enriched miRNAs are depleted temporally in ALS rodent.

Gautam B. Awatramani, Gareth D. Price, Laurence O. Trussell Neuron

Gilberto J Soler-Llavina, Miguel Holmgren, Kenton J Swartz Neuron

Receptive-Field Modification in Rat Visual Cortex Induced by Paired Visual Stimulation and Single-Cell Spiking C. Daniel Meliza, Yang Dan Neuron Volume.

Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice Pan-Yue Deng, Vitaly A. Klyachko

Importance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes

Implicit adaptation generalizes around the aiming location (30° CCW)

Koen Vervaeke, Hua Hu, Lyle J. Graham, Johan F. Storm Neuron

Volume 39, Issue 3, Pages (July 2003)

Volume 97, Issue 6, Pages e3 (March 2018)

Excitability of the Soma in Central Nervous System Neurons

Light illumination excites Lamina I SDH neurons after PNI

Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 Channels

Zare Melyan, Howard V. Wheal, Barrie Lancaster Neuron

TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels

Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output Functions Tiago P. Carvalho, Dean V. Buonomano

Selective modulation of AMPAR-mediated transmission in 4E-BP2−/− mice.

Kv2. 1-like currents are related linearly to estimates of Kv2

Action potentials rely on voltage-gated sodium channels to propagate into the dendrite. Action potentials rely on voltage-gated sodium channels to propagate.

CX3CR1 deficiency impairs the functional maturation of thalamocortical synapses. CX3CR1 deficiency impairs the functional maturation of thalamocortical.

Characterization of non-DA firing.

Effects of MPH on 19 single neuron response metrics.

Qualitative effects of MPH on the average single neuron response.

Relationship between spiking and 5K signal in vivo.

Ih activation is required for sigh but not for eupnea generation.

Averaged LSPS-induced excitation maps obtained from pyramidal and fast-spiking neurons in Layer II/III IC of sham and 1w-IANX rats. Averaged LSPS-induced.

Application of GABA to nucleated patches from dentate granule cells induces SR95531-sensitive channel openings. Application of GABA to nucleated patches.

Expansion of RF size of VPM units after IANx

LFP findings from the PPC during performance on the visual target-detection task. LFP findings from the PPC during performance on the visual target-detection.

Diagram depicting the location of electrode placement.

Voltage dependence of TTX-R sodium channel slow inactivation.

Light illumination activates primary afferents with conduction velocity in a range of Aβ fibers. Light illumination activates primary afferents with conduction.

Scn11a gene inactivation shortens AP duration and impairs firing discharge. Scn11a gene inactivation shortens AP duration and impairs firing discharge.

Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments Delia N. Chiu, Craig E. Jahr Cell Reports

GABAergic synaptic inhibition is not altered in MGB neurons of tinnitus rats. GABAergic synaptic inhibition is not altered in MGB neurons of tinnitus rats.

Calibration of the voltage dependence of spine ΔF/F using optical recordings in spines of bAPs. Calibration of the voltage dependence of spine ΔF/F using.

BACHD mice demonstrate decreases in synaptic activity of medium-sized spiny neurons at 6 months. BACHD mice demonstrate decreases in synaptic activity.

Volume 33, Issue 4, Pages (February 2002)

Paraquat induces selective loss of subsets of dopaminergic neurons.

Knock-out of NSG2 decreases mEPSC frequency.

ACC encodes expected reward size, but not delay (n = 38)

SSC LTP in narrow-field vertical neurons is induced by SO stimulation at 20 Hz for 20 s. sSC LTP in narrow-field vertical neurons is induced by SO stimulation.

A, Representative examples of Ca currents elicited by repetitive 3 Hz depolarizing voltage steps to 0 mV from a holding potential of −40 mV from a CA1.

A, Representative voltage-clamp recordings from a CRF1+ neuron during superfusion of GBZ (100 μm), followed by PTX (100 μm, top trace) and during superfusion.

Leptin-mediated electrophysiological activation of POMC neurons.

Increased spike ADP in pilocarpine-treated rats is sensitive to spermine. Increased spike ADP in pilocarpine-treated rats is sensitive to spermine. A,

Presentation transcript:

Increased INaP in CA1 pyramidal neurons from pilocarpine-treated rats. Increased INaP in CA1 pyramidal neurons from pilocarpine-treated rats. A, Isolated INaP was evaluated in voltage-clamped CA1 pyramidal neurons by applying a slow voltage ramp before (Icontrol, black) and after application of TTX (ITTX, blue; top traces). The recorded traces were then subtracted from each other (Icontrol − ITTX, gray), and the resulting TTX-sensitive current (INaP) was mathematically converted to conductance (GNaP). By fitting a Boltzmann function to the G/V plot, Gmax was determined for every neuron. B, Average G/V plots (n = 14 for sham-control, n = 15 for pilocarpine-treated ; SEM depicted in gray) illustrate the increase of INaP in CA1 pyramidal neurons from pilocarpine-treated rats. C, Average G/V plots of the same neurons, normalized to Gmax, reveal a slight but significant shift in the voltage of half-maximal activation in pilocarpine-treated compared with sham-control rats (p = 0.014, unpaired t test with Welch's correction). Presentation of SEM was omitted for clarity. D, Average G/V plots of CA1 neurons recorded at different temperature (20°C and 32°C, n = 5 for each temperature) show no difference in Gmax and V50 (p = 0.72 and 0.52, respectively, Student's t test) and a significant steeper slope at 20°C (p = 0.02, Student's t test). Michel Royeck et al. J. Neurosci. 2015;35:15240-15253 ©2015 by Society for Neuroscience