Circulating leukocytes do not efficiently infiltrate advanced solid tumors in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Circulating leukocytes do not.

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Circulating leukocytes do not efficiently infiltrate advanced solid tumors in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Circulating leukocytes do not efficiently infiltrate advanced solid tumors in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Cytofluorimetric tracking of circulating leukocytes in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Spleen and lymph nodes cells from 10.5-wk-old CD45.1+ congeneic RIP1-Tag2 mice were stained with CFSE and transferred into age-matched CD45.2+ RIP1-Tag2 mice. Recipients were treated with IL-15/IL-15Rα complexes at the time of donor leukocyte infusion and the distribution of CD45.1+ CFSE-labeled donor leukocytes was subsequently evaluated 24, 48, and 72 h later by cytofluorimetry (n = 6 mice per condition). A, dot plots depict CD45.1+ donor cells (X axis) versus forward size scatter (FSC; Y axis). B, histograms depict proliferation of CFSE+ donor cells (X axis). C, quantification of tumor burden in IL-15/IL-15Rα complex–treated (n = 16) and control (n = 21) RIP1-Tag2 mice at 48 h of treatment. Columns, mean for individual mice (represents four independent experiments); bars, SE. Mathieu Epardaud et al. Cancer Res 2008;68:2972-2983 ©2008 by American Association for Cancer Research