New directions for enhanced 13C imaging of brain cancer.

Slides:

Advertisements

Similar presentations

Top row, Images from a coronally oriented cine CT scan of the rabbit brain from the level of the pons (section 1) to the parieto-occipital cerebrum (section.

Advertisements

Precontrast coronal T1-weighted view shows metastatic nodules (long arrows) from breast cancer in the vicinity of the left BPL and another metastatic mass.

Demonstration of the creation of a patient-specific brain mold for minimizing tissue distortion during fixation. Demonstration of the creation of a patient-specific.

Anti-N-methyl D-aspartate receptor encephalitis.

123I/Tc-99m sestamibi subtraction scan (top left); neck sonogram in region of cystic mass (top right); axial arterial phase CT scan (bottom left); and.

Graph (box plots) shows primary tumor volumes of oral and maxillary sinus (A) and pharyngeal (B) cancers categorized at T1–T4. Graph (box plots) shows.

Longitudinal MWF in different brain regions for the vaginal delivery (blue) and cesarean delivery (green) groups in cohort 3. Longitudinal MWF in different.

Histology samples stained with Masson trichrome.

Image shows appearance of septum within dural sinus in a 68-year-old woman with normal results of an MR imaging examination. Image shows appearance of.

A 61-year-old man with brain metastases from primary lung cancer.

Contrast-enhanced T1WI (A and C) and CBF maps derived from ASL imaging (B and D) for 2 representative cases. Contrast-enhanced T1WI (A and C) and CBF maps.

A, Measurement of the angle between the TS-OP line and the hard palate in the lateral scout view of the brain CT (black arrow). A, Measurement of the angle.

Receiver operating characteristic curves with statistical significance are shown. Receiver operating characteristic curves with statistical significance.

Normalized and averaged images of rGMC and I-123 iomazenil BP

A, Axial source image from a contrast-enhanced MRA unambiguously demonstrates a tiny (

Contrast-enhanced coronal CT scan of a rabbit.

Serial axial T2-weighted images (2000/110/2 at treatment, 3400/100/4 at 6 months and 4000/100/3 at 10 months and 36 months after treatment) in a 52-year-old.

A side-by-side comparison of EPVS in a cognitively healthy control versus a patient with aMCI A, A coronal MR brain image of a cognitively healthy control.

FLAIR scan, FA map, and fiber tracking in a 38-year-old patient with TBI who was imaged 2 weeks after the initial trauma. FLAIR scan, FA map, and fiber.

Images obtained in a 67-year-old woman with posttreatment glioblastoma who had ETP. Contrast-enhanced, T1-weighted imaging (A) performed 4 weeks after.

Coronal gadolinium-enhanced T1-weighted image (TR/TE/NEX, 500/15/2) at the level of the foramen ovale shows a significantly enhancing V3 branch (arrow)

T2-weighted images of a patient with an infarction within the anterior MCA branch territory on day 5 (patient 15) show high SI changes within the ipsilateral.

Bar graph of the number of averaged activated voxels (normalized to control values), as defined by increases in lactate concentration in the left frontal.

A and B, Axial and coronal high-resolution CT images of the larynx in a 73-year-old patient with papillary thyroid cancer and left vocal cord paralysis.

Postmyelography CTs showing (A) bilateral cervicothoracic CSF leaks without an associated meningeal diverticulum; B, Left thoracic meningeal diverticulum.

Bony cochlear nerve canal atresia in a patient with CND

T2-weighted, PD-weighted, FLAIR, and DWI images showing cortical abnormalities in the right parietal lobe; FLAIR and DWI also show abnormalities in the.

Transverse FLAIR (bottom row) and DIR (top row) sections of the supratentorial brain. Transverse FLAIR (bottom row) and DIR (top row) sections of the supratentorial.

Trends in the use of head CT and advanced imaging in patients treated with IV thrombolysis from 2008 to Trends in the use of head CT and advanced.

A 51-year-old woman with glioblastoma multiforme.

A–C, DWI scan (A) shows acute infarction involving the left cerebellar hemisphere, which appears iso- to hyperintense on the b0 EPI scan (B). A–C, DWI.

Images of a 37-year-old man who was a pedestrian in a traffic accident in January 1992; he was hit by an automobile while under the influence of alcohol.

Bar graph of ADC values (s/mm2) for tumor, contralateral normal tissue, ipsilateral normal tissue, and edema for the group of 15 patients with high-grade.

A 49-year-old man with abducens nerve palsy from a partially thrombosed PICA aneurysm projecting into the brain stem. A 49-year-old man with abducens nerve.

Representative multislice MIP projections of EPVS in the subcortical brain structures and the basal ganglia of a control and a subject with aMCI. Representative.

Basilar artery diameter measured with CTA in the delayed stage of SAH

Graph of neurologic scores (mean ± SD) for the moderate-severe VSPdelayed group, mild VSPdelayed group, and sham group. Graph of neurologic scores (mean.

Coronal postcontrast T1-weighted image of the orbits in patient 1 demonstrates a heterogeneously enhancing ovoid lesion involving the right medial rectus.

Examples of tumor classifications are as follows: circumscribed, with sharp smooth borders (A); circumscribed, with sharp borders, but not smooth due to.

Coronal T1-weighted contrast-enhanced MR image obtained in January of 1999 at the onset of right hearing impairment shows increased enhancement of the.

Differentiation of common pediatric brain tumors by quantitative 1H-MR spectroscopy. Differentiation of common pediatric brain tumors by quantitative 1H-MR.

3D angiogram shows a vertebrobasilar junction aneurysm on the bridging artery of a basilar fenestration. 3D angiogram shows a vertebrobasilar junction.

Bone algorithm CT images from the same case, demonstrating focal enlargement of the right tympanic segment, in the axial (left) and coronal (right) planes.

Dynamic contrast-enhancement curves for patients with SLE (blue) and healthy controls (red) according to the brain regions sampled. Dynamic contrast-enhancement.

Z-score brain surface map represents the result of group comparison between 2 healthy subjects groups such as control group (CG) and data base group (DBG).

A and B, The ROC curves analyzing the sensitivity and specificity of the WHO grading system (I-IV) for the 1-year survival (A) and recurrence (B) show.

Axial head CT image across the centrum semiovale before (baseline image) and after (enhanced image) processing with CIE, with equivalent ROIs used to measure.

Stiffness heterogeneity of gliomas.

A–C, FLAIR (TR/TE, 9002/149. 5), DWI (10000/105

MR images of the brain (axial sections, fluid-attenuated reversion recovery sequences) show the symmetric hyperintensities (arrows) involving the pyramidal.

A 43-year-old male patient with headaches (case 33).

Relationships between the AI in the subacute stage and neurologic state. Relationships between the AI in the subacute stage and neurologic state. No significant.

Relationships between number and site of traumatic microbleeds and clinical and imaging parameters. Relationships between number and site of traumatic.

Scatter and box plot of midpoint measurement compared with age of subject. Scatter and box plot of midpoint measurement compared with age of subject. The.

Spatial orientation of the thalami.

Images from 1988 obtained in a patient with AIDS with CMV-induced ARN preceding retrobulbar optic neuritis.A, CT scan shows a shrunken left globe with.

Representative quantitative maps of a patient with brain metastasis.

Axial T2-weighted MR image shows normal flow void in the right internal jugular vein (arrows), whereas flow-related enhancement can be seen in the left.

A, Postcontrast T1-weighted MR image of the brain during metastatic work-up demonstrates no metastatic disease. A, Postcontrast T1-weighted MR image of.

ADC and astrocytoma grade.

Brain MR imaging 2 hours after onset of symptoms

A, T2-weighted coronal image shows a soft-tissue mass of intermediate signal intensity in the left posterior nasal cavity.B, Postcontrast T1-weighted axial.

Plots of the difference between sonography and MR imaging ventricular measurements against the time interval between sonography and MR imaging. Plots of.

Axial images from the brain of a 59-year-old woman with mixed features of response, including areas of treatment-related changes and TP. Contrast-enhanced.

Boxplots of diffusion (A and B) and perfusion (C) characteristics in brain metastases (gray), glioblastomas (white), and PCLs (dotted). Boxplots of diffusion.

FIG 4. Plots of the Loes scores, based on double-echo spin-echo MR images, obtained at different follow-up examinations for 22 patients with ALD. The T1-weighted.

Comprehensive imaging of a patient with recent stroke depicting left MCA stenosis. Comprehensive imaging of a patient with recent stroke depicting left.

Magnified lateral projections of bilateral ICA angiography (A, right; -B, left) show only minimal collateral flows (arrows) from lenticulostriates over.

Left, T1 spin-echo image at 1

Illustration of the point-counting technique applied to estimate hippocampal volume from MR images of a control (C, top row), patient with left-sided seizure.

Presentation transcript:

New directions for enhanced 13C imaging of brain cancer. New directions for enhanced 13C imaging of brain cancer. Immunocytochemical stain for the hypoxia-induced factor (HIF)-1α indicates glioblastoma to be particularly rich in this cancer biomarker protein. This may, in the future, provide a uniquely sensitive means of in vivo imaging of brain cancer grade and metabolic activity (see Fig 13). RENCA, renal cancer; A-20-A (top left, top right, and bottom right ×160; bottom left ×312). (Courtesy of Dr. Ashraf Imam). B.D. Ross et al. AJNR Am J Neuroradiol 2010;31:24-33 ©2010 by American Society of Neuroradiology