Effect of NO and eNOS on prostate cancer cell growth.

Slides:

Advertisements

Similar presentations

Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Potentially Harmful Effect of a Testosterone Dietary.

Advertisements

CDK2 is highly expressed in colon cancer cells and curcumin selectively suppresses HCT116 cell proliferation. CDK2 is highly expressed in colon cancer.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Quantification of the significantly changed metabolites.

Effect of quercetin on colony-forming abilities of prostate cancer cell lines with different aggressive potentials. Effect of quercetin on colony-forming.

CHK1 downregulation upon ERG overexpression.

Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages.

The selective PI3K inhibitor A66 suppresses PIP3 accumulation, AKT phosphorylation at Thr308, and YAP/TAZ–regulated gene expression in PDAC cells. The.

Fig. 4. Seeding density modulates cell shape in both cell types

Effect of insulin on hepcidin expression in HepG2 cells.

USP2a regulates MYC expression through the MDM2–p53 axis.

PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PKIs block DHT + bombesin-induced transactivation.

ASyn overexpression exacerbates the effect of MPP+ on Ca2+ in SN but not VTA neurons. aSyn overexpression exacerbates the effect of MPP+ on Ca2+ in SN.

Adipocytes sequester daunorubicin (DNR).

Effect of the PD-1–B7-H1 interaction on cell proliferation potential and drug sensitivity in MOSTI-1 cells. Effect of the PD-1–B7-H1 interaction on cell.

In vitro binding and specificity of OTL78.

Cytokine expression in the ileum and colon.

In vivo efficacy and specificity of OTL78 in orthotopic and subcutaneous tumor models using the AMI image system. In vivo efficacy and specificity of OTL78.

FOXO1 inhibits Runx2-induced invasion of prostate cancer cells.

The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle distribution. The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle.

VEGF expression in neoplastic and normal prostate tissue.

Induction of cell death in prostate cancer cells by SAHA and ZOL

Overexpression of L1 in CRC cells induces NF-κB activation and suppression of p65 expression blocks the capacity to confer liver metastasis. Overexpression.

IL-13Rα2 promotes cell survival and proliferation.

The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A,

Reconstitution of RhoH expression in HCL inhibits homotypic adhesion.

High-throughput siRNA screening results and corresponding patient gene expression data for PP2A subunits. High-throughput siRNA screening results and corresponding.

A and B, mRNA expression relative to ERα (in%) for ZNF423 (A) and BRCA1 (B) for LCLs of known genotypes for variant (V) and WT chromosome 16 ZNF423 SNPs.

Overexpression of EP4 with cAMP-PKA signal activation promoted the castration-resistant progression of LNCaP cells through AR activation. Overexpression.

The AKT–mTOR pathway controls PD-L1 protein expression.

GPC3 promotes hepatocellular carcinoma growth by stimulating the canonical Wnt pathway (A-B) GPC3 induces the stabilization of cytoplasmic β-catenin. GPC3.

Role of MAPKs on DPP-23-induced autophagy and apoptosis.

Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma cells. Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma.

IL8 and TNFα are required for neutrophil-induced UMSCC47 increase in invasion. IL8 and TNFα are required for neutrophil-induced UMSCC47 increase in invasion.

FACS analyses of the inhibitory effect induced by mixed docetaxel, gefitinib, and cyclopamine on EGF plus SHHNp–stimulated PC3 cells. FACS analyses of.

Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. LNCaP,

The effect of different concentrations of WMC-79 and time of exposure on the growth of HCT-116 cells. The effect of different concentrations of WMC-79.

Neurotensin and insulin induce increases in CTGF, CYR61, and CXCL5 gene expression and stimulate cell proliferation and colony via YAP/TAZ in PDAC cells.

Induction of liver NQO1 activity in juvenile female rats treated for 3 d (10 mg/kg qd SERMs or 0.1 mg/kg qd E2 or vehicle control). Induction of liver.

Carcinoma cell–secreted IL-1 induces PGE2 production in MSCs

WP1066 inhibits the progression of OCIM2 cells through the cell cycle.

Expression of the cell death markers activated caspase-3 and LC3 I/II in TUBO cells. Expression of the cell death markers activated caspase-3 and LC3 I/II.

A combination of neurotensin and insulin potently decreases YAP phosphorylation at Ser127 and Ser397 in PDAC cells. A combination of neurotensin and insulin.

C-MYC overexpression or growth in serum-containing media induces EMT in HBEC3p53,KRAS. c-MYC overexpression or growth in serum-containing media induces.

EMT alters activation of AKT and serum-independent proliferation.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

AR is transnitrosylated by HSP90.

The effects of 5α-dihydrotestosterone and growth factors (insulin-like growth factor I and epidermal growth factor) on LNCaP cell proliferation. The effects.

MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.

Pdcd4 expression inhibits AP-1 transactivation.

Trametinib and combination promote moDC maturation and decrease moDC viability. Trametinib and combination promote moDC maturation and decrease moDC viability.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

Transcriptional activity and growth of mutant ER in a breast cancer cell line. Transcriptional activity and growth of mutant ER in a breast cancer cell.

Adhesion of T-cell clones to autologous tumor cells under shear stress

Metabolic profiling and characterization of reliance on de novo lipid synthesis of prostate cell lines. Metabolic profiling and characterization of reliance.

AS1411 alters subcellular distribution of PRMT5 in a time-dependent, dose-dependent, and nucleolin-dependent manner. AS1411 alters subcellular distribution.

SAHA blocks IR-induced increase of RAD51 protein in MM cells.

A, cell number was assessed 96 hours after exposure to indicated treatment in indicated cell models. A, cell number was assessed 96 hours after exposure.

Functional SLC6A3 in ccRCC cell lines KMRC3 and SNU-349, but not in conventional cell lines. Functional SLC6A3 in ccRCC cell lines KMRC3 and SNU-349, but.

AKT activation in HCC2429 is SRC- but not Notch-dependent.

AXL overexpression decreases proliferation in vitro.

Effect of MIF siRNA on the production of MMP-13 induced by LPA

W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells.

Sorafenib inhibits cell proliferation and induces apoptosis in HCC cells. Sorafenib inhibits cell proliferation and induces apoptosis in HCC cells. A,

Effects of W. chinensis extract on androgen activity and growth of prostate cancer cells. Effects of W. chinensis extract on androgen activity and growth.

AR promotes DNA double-strand break resolution.

Wild-type and oncogenic Ras differentially regulate cell proliferation

Curcumin decreases viability and proliferation of Bcr-Abl-expressing cells. Curcumin decreases viability and proliferation of Bcr-Abl-expressing cells.

NUAK1 overexpression correlates with tumor progression, lymph node infiltrates, and reduced overall survival (OS) in human colorectal cancer. NUAK1 overexpression.

Effects of inhibitors of PI3K, MEK1, and GSK-3β on visfatin-induced proliferation in HepG2 cells. Effects of inhibitors of PI3K, MEK1, and GSK-3β on visfatin-induced.

Presentation transcript:

Effect of NO and eNOS on prostate cancer cell growth. Effect of NO and eNOS on prostate cancer cell growth. Effect of DETA-NO on LNCaP (A), 22Rv1 (B), and PC3 (C) cell proliferation. Equal number of cells was incubated for 24 hours in appropriate culture medium containing 10% FBS in the presence or absence of DETA-NO. For each time point, viable cells were determined after mixing with WST-1 and data are expressed as fold change in absorbance at A450, for which the value of untreated cells that were incubated for 8 hours was defined as 1. *, P < 0.05 compared with corresponding nontreated (NT) control cells, and #, P < 0.05 compared with nontreated control cells at 8 hours. D, doubling times of LNCaP cells stably overexpressing eNOS or sheNOS were calculated by counting viable cells at 24 hours interval. *, P < 0.05 compared with control LNCaP-EV cells. E, forced overexpression of eNOS attenuates the androgen-induced LNCaP cell proliferation. LNCaP-eNOS and LNCaP-EV cells were treated with DHT (10 nmol/L) or R1881 (1 nmol/L) for 96 hours and viable cell numbers were counted. *, P < 0.05 compared with control LNCaP-EV cells; #, P < 0.05 compared with corresponding LNCaP-eNOS cells. In all panels, the Tukey post hoc test following a one-way ANOVA was performed to compare groups. All results represent three independent experiments. Yu Qin et al. Cancer Res 2013;73:6690-6699 ©2013 by American Association for Cancer Research