Monitoring the epitope recognition profiles of IgE, IgG1, and IgG4 during birch pollen immunotherapy Barbara Gepp, MSc, Nina Lengger, BMA, Christian.

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Presentation transcript:

Monitoring the epitope recognition profiles of IgE, IgG1, and IgG4 during birch pollen immunotherapy Barbara Gepp, MSc, Nina Lengger, BMA, Christian Möbs, PhD, Wolfgang Pfützner, MD, Christian Radauer, PhD, Barbara Bohle, PhD, Heimo Breiteneder, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 5, Pages 1600-1603.e1 (May 2016) DOI: 10.1016/j.jaci.2015.10.022 Copyright © 2015 The Authors Terms and Conditions

Fig 1 Bet v 1–specific IgE, IgG1, and IgG4 responses of 11 patients during AIT with birch pollen. Relative absorbance values are based on the highest value (= 100%) within each isotype for each patient. Journal of Allergy and Clinical Immunology 2016 137, 1600-1603.e1DOI: (10.1016/j.jaci.2015.10.022) Copyright © 2015 The Authors Terms and Conditions

Fig 2 IgE, IgG1, and IgG4 binding to Api g 1 and the 4 Bet v 1–specific areas on chimeras of 11 patients during AIT with birch pollen. OD values for Api g 1 (scaffold protein) were subtracted from chimera-specific OD values. Journal of Allergy and Clinical Immunology 2016 137, 1600-1603.e1DOI: (10.1016/j.jaci.2015.10.022) Copyright © 2015 The Authors Terms and Conditions

Fig E1 Structural comparison of Bet v 1, Api g 1, and the 4 chimeras. Front and back views (rotated by 180° around a vertical axis) of the parent molecules and chimeras are depicted. At right, views centered at the Bet v 1–specific areas on the chimeras are shown. Journal of Allergy and Clinical Immunology 2016 137, 1600-1603.e1DOI: (10.1016/j.jaci.2015.10.022) Copyright © 2015 The Authors Terms and Conditions