Effect of IS on proliferation, senescence, and the production of NO and ROS from endothelial cells. Effect of IS on proliferation, senescence, and the.

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Effect of IS on proliferation, senescence, and the production of NO and ROS from endothelial cells. Effect of IS on proliferation, senescence, and the production of NO and ROS from endothelial cells. IS induced a dose-dependent inhibition of proliferation (A), an increase in cell senescence (B), and a decrease in NO production (C) from a concentration of 0.25 mg/dl at 24 and 48 hours. IS-induced changes in HUVEC were blocked by probenecid (P). Data show the average of four separate experiments performed in duplicate. *P < 0.05 versus others at each time point, †P < 0.05 versus 0, 0.25 of IS and the conditions with probenecid. IS at the concentrations above 0.25 mg/dl also increased ROS generation from 10 minutes of stimulation (D). Hydrogen peroxide (0.1 mM) was used for positive control inducing oxidative stress in HUVEC. Data show the average of four separate experiments performed in duplicate. *P < 0.05 versus control (0 minutes), †P < 0.05 versus control and IS-containing conditions at 10 and 30 minutes. Mina Yu et al. CJASN 2011;6:30-39 ©2011 by American Society of Nephrology