Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats Shen-Kou Tsai, MD, PhD, Li-Man Hung, PhD,

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Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats Shen-Kou Tsai, MD, PhD, Li-Man Hung, PhD, Yuan-Tsung Fu, MD, Henrich Cheng, MD, PhD, Mao-Wei Nien, Hsin-Yi Liu, BS, Friedrich Bo-Yuan Zhang, BS, Shiang-Suo Huang, PhD Journal of Vascular Surgery Volume 46, Issue 2, Pages 346-353 (August 2007) DOI: 10.1016/j.jvs.2007.04.044 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Western blot analyses of brain tissue after FCI injury for iNOS, eNOS, nNOS, and β-actin in rats. Rats were treated with vehicle or resveratrol at a dose of 1 μg/kg when the common carotid arteries clips were removed. Data were normalized with β-actin and expressed as percentage rate. Each value represents the mean of seven individual experiments. Results are expressed as mean ± SEM. *P < .05 compared with vehicle group. S = sham group, non-ischemic operated rats; V = vehicle-treated group; R = resveratrol-treated group. Journal of Vascular Surgery 2007 46, 346-353DOI: (10.1016/j.jvs.2007.04.044) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 Analysis of iNOS, eNOS, nNOS, and β-actin mRNA expression of brain tissue in rats after FCI injury. Rats were treated with vehicle or resveratrol at a dose of 1 μg/kg when the common carotid arteries clips were removed. S = sham group, non-ischemic operated rats; V = vehicle-treated group; R = resveratrol-treated group. Journal of Vascular Surgery 2007 46, 346-353DOI: (10.1016/j.jvs.2007.04.044) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 Effect of resveratrol in the levels of MDA on FCI injury rats. Each experimental group is seven rats. Values are expressed as mean ± SEM. *P < .05 compared with vehicle group. Journal of Vascular Surgery 2007 46, 346-353DOI: (10.1016/j.jvs.2007.04.044) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 4 Effect of NOS inhibitors on the neuroprotective effect of resveratrol in FCI injury rats. Each experimental group is seven rats. Values are expressed as mean ± SEM. *P < .05 compared with vehicle group. #P < .05 compared with resveratrol group. L-NAME (1 mg/kg; i.v.): nonselective NOS inhibitor. 7-nitroindazole (50 mg/kg; i.p.): nNOS selective inhibitor. S-methylisothiourea: (3 mg/kg; i.p.): iNOS selective inhibitor. L-NIO (10 mg/kg; i.p.): eNOS selective inhibitor. Journal of Vascular Surgery 2007 46, 346-353DOI: (10.1016/j.jvs.2007.04.044) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions