LRP1 is necessary for rK5-induced apoptosis of primary human brain MvEC. LRP1 is necessary for rK5-induced apoptosis of primary human brain MvEC. Irradiated.

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LRP1 is necessary for rK5-induced apoptosis of primary human brain MvEC. LRP1 is necessary for rK5-induced apoptosis of primary human brain MvEC. Irradiated (A) and unirradiated (B) primary human brain MvEC were treated with rK5 or vehicle (as described in Fig. 1) or recombinant receptor-associated protein (rec-RAP) and then subjected to TUNEL assay or detergent lysed and immunoblotted with the indicated antibodies. C, primary human brain MvEC were irradiated and immediately treated with siRNA for 20 h, replated, and treated with siRNA for an additional 4 h followed by treatment with rK5 or vehicle (17 h) and then subjected to a TUNEL assay. D, primary human brain MvEC were treated with siRNA for 48 h, replated, and treated with rK5 or vehicle (17 h) and then subjected to a TUNEL assay. TNF-α induction of apoptosis was used as a positive control in the TUNEL assays. Braden C. McFarland et al. Cancer Res 2009;69:5537-5545 ©2009 by American Association for Cancer Research