The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity Patricia.

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Presentation transcript:

The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity Patricia Díaz-Gimeno, Ph.D., Maria Ruiz-Alonso, Ph.D., David Blesa, Ph.D., Nuria Bosch, M.D., José A. Martínez-Conejero, Ph.D., Pilar Alamá, M.D., Nicolás Garrido, Ph.D., Antonio Pellicer, M.D., Carlos Simón, M.D. Fertility and Sterility Volume 99, Issue 2, Pages 508-517 (February 2013) DOI: 10.1016/j.fertnstert.2012.09.046 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Endometrial dating in different phases of the menstrual cycle. The graphics show endometrial dating in proliferative, prereceptive, receptive, and postreceptive phases. Failures and hits are shown as percentages for each method and endometrial phase. ERA = endometrial receptivity array; P1 = pathologist 1; P2 = pathologist 2. Fertility and Sterility 2013 99, 508-517DOI: (10.1016/j.fertnstert.2012.09.046) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Consistency of the endometrial receptivity array (ERA) test. (A) Consistency pairs are described in this table. The endometrial phase that belongs to each pair. PF = proliferative phase; PR = prereceptive phase; R = receptive phase; PS = postreceptive phase; months between each sample collection; first and second ERA test diagnoses from the same patient. NR = nonreceptive diagnosis. The diagnostic probability of the ERA test is shown in parenthesis. (B) Principal component analysis of the ERA gene expression training set and reproducibility set. The points represent the samples in relation to 238 expressed genes. Proliferative samples are shown in red, prereceptive in blue, receptive in green, and postreceptive in purple. Each consistency pair is represented by the same letter (A to G), with a border circle in the same color of the endometrial phase as the first ERA test, and in gold the second ERA test. PC1, PC2 = first and second principal components that explain the highest variability that separates samples in the space. Fertility and Sterility 2013 99, 508-517DOI: (10.1016/j.fertnstert.2012.09.046) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions