Schematic model illustrating how paracrine signaling drives LPS-stimulated cytokine secretion. Schematic model illustrating how paracrine signaling drives.

Slides:

Advertisements

Similar presentations

by Kevin J. Paavola, Harwin Sidik, J

Advertisements

Kusumawadee Utispan, Sittichai Koontongkaew

Principles of Immunology Cytokines

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Target recognition–induced NK-cell responses

Figure 1 Associations between baseline cerebrospinal fluid

Figure 1 A schematic representation of the role

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Levels of cytokines and chemokines in TPL-treated (from ED2) and control (H2O) mice at midgestation (ED10). Levels of cytokines and chemokines in TPL-treated.

Cytokines and Chemokines Chapter 6

S534 phosphorylation affects DNA binding and gene expression by NF-κB at late time points through regulation of p65 stability. S534 phosphorylation affects.

Effect of moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide F.G. Araujo, T.L. Slifer, J.S. Remington Clinical.

Pg and Ec LPS induced levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Pg and Ec LPS induced levels.

Mechanisms of immune escape in the tumor microenvironment.

L. Y. A. Chai, R. Naesens, A. L. Khoo, M. V. Abeele, K

Comparison of cytokine profiles induced by ChiLob 7/4 and TLR ligands in ex vivo whole-blood stimulation assays. Comparison of cytokine profiles induced.

Unstimulated levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Unstimulated levels of soluble mediators.

Table S1: Characteristics of the cancer patients

Nikhil Dhingra, Emma Guttman-Yassky

The landscape of cytokine-producing CD4 T cell populations in the peripheral blood (PB) and in the joints. Venn diagrams show the frequency of overlapping.

Jill A. Poole, MD, Neil E. Alexis, PhD, Conrad Parks, BS, Amy K

Tumor-Associated Macrophages: From Mechanisms to Therapy

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Role of TLR signaling in hY4-induced changes and effects of TLR inhibition. Role of TLR signaling in hY4-induced changes and effects of TLR inhibition.

David C. Soler, Thomas S. McCormick

Measurement of a) IL-8, b) IL-6 and c) GM-CSF release by BEAS-2B cells stimulated with deoxycholic acid for 48 h. Measurement of a) IL-8, b) IL-6 and c)

Lec.9 Cytokines.

DC subset cooperation for activation of antiviral T cells.

Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.

Figure 1 The role of macrophages in RA

Effect of YopM on the transcription of pro-inflammatory cytokines in HL60-derived macrophages after stimulation with LPS. HL60 cells differentiated into.

Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering.

Consolidated Standards of Reporting Trials flow diagram of VRC trial

IL-10–dependent regulation of intestinal health.

Figure 2 Effect of DMF therapy on the T helper cell repertoire and cytokine production Effect of DMF therapy on the T helper cell repertoire and cytokine.

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell–mediated allergic inflammation Yong-Jun Liu, MD, PhD Journal.

NK cell immune evasion occurs through loss of TNF pathway members.

Alternatively activated macrophages as therapeutic agents for kidney disease: in vivo stability is a key factor Senthilkumar Alagesan, Matthew D. Griffin

CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.

Schematic model of the mechanism of Tak1 protection of HSPC survival.

IL-10–producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients Antje Prasse, MD, Martin Germann,

DPP-4 enhances M1 polarization and inhibits M2 polarization in macrophages in an ROS-dependent manner. DPP-4 enhances M1 polarization and inhibits M2 polarization.

Fig. 4. Long-term persistence of CTL019 cells and polyfunctionality in patients achieving CR. Long-term persistence of CTL019 cells and polyfunctionality.

The microchip-based drug delivery device and overview of study design

Fig. 2 CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity. CAR T cell therapy is associated with cytokine release syndrome.

Cytokine changes in LPS-induced TNFα and spontaneous IL-6 production in whole-blood cultures. Cytokine changes in LPS-induced TNFα and spontaneous IL-6.

Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria and worsened colitis upon.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

Inhibition of TGF-β signaling abrogates the conversion of glutamine-deprived CD4+ T cells to Treg cells but cannot support TH1 cell generation. Inhibition.

Fig. 3 ERK5 inhibition suppresses M2 macrophage polarization, alters secreted cytokine profiles, and modifies the actin cytoskeleton. ERK5 inhibition suppresses.

by Gonghua Huang, Yanyan Wang, Peter Vogel, and Hongbo Chi

Effect of anti-cyCD79b (10D10) and anti-cyCD79b (10D10)-MCC-DM1 on cytokine levels in cynomolgus monkeys. Effect of anti-cyCD79b (10D10) and anti-cyCD79b.

by Jianghong Zhong, Tatjana Scholz, Anthony C. Y

Schematic representation of the interrelationship between monocyte differentiation, NF-κB accumulation and translocation, and TNF-α secretion. Schematic.

T cell effector cytokines and staphylococcal products regulate CCL18.

Paracrine signaling enhances cytokine secretion by isolated cells.

Treg expression of Gata3 plays a major role in controlling dermal fibrosis. Treg expression of Gata3 plays a major role in controlling dermal fibrosis.

Fig. 4. Plaque-associated microglia and astrocytes and brain cytokines were altered in APP/PS1;C3 KO mice compared to APP/PS1 mice. Plaque-associated microglia.

Candesartan diminishes SynO-mediated morphofunctional responses in microglia. Candesartan diminishes SynO-mediated morphofunctional responses in microglia.

Human basophils are unresponsive to contact-dependent or contact-independent inhibition by Tregs. Human basophils are unresponsive to contact-dependent.

ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N mice. ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N.

Fig. 7 BEL immune response.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Fig. 7 Differences in the tumor microenvironment between transplant and transgenic BRAFV600E-driven melanoma models may underlie refractoriness of iBIP2.

Fig. 5 IL-5–mediated signaling is critical for the development of CD1dintCD5+ Breg precursor cells and IL-10+ Breg cells. IL-5–mediated signaling is critical.

Acute circadian disruption alters ILC3 cytokine secretion.

Fig. 3. Association between peak CTL019 expansion and response.

Circadian gene expression in ILC3s is associated with rhythmic cytokine expression. Circadian gene expression in ILC3s is associated with rhythmic cytokine.

Meningeal γδ T cell homeostasis is independent of inflammatory signals

Presentation transcript:

Schematic model illustrating how paracrine signaling drives LPS-stimulated cytokine secretion. Schematic model illustrating how paracrine signaling drives LPS-stimulated cytokine secretion. Most macrophages stimulated with LPS secrete CCL4, CCL5, and IL-8, whereas a smaller percentage of cells secrete IL-1β, TNF-α, GM-CSF, IL-6, and IL-10. The secretion of IL-6 and IL-10 is dependent on paracrine signals from the subset of cells that secrete IL-1β, TNF-α, GM-CSF, and other factors not measured in our study. The secretion of IL-10 further depends on paracrine signaling by IL-6. IL-10 is the cytokine whose secretion was most adversely affected by the isolation of MDM cells. Cells that secrete IL-10 inhibit the secretion of TNF-α, GM-CSF, and IL-6, as well as of some chemokines (21, 32, 33), which may account for the increased concentrations of TNF-α and GM-CSF that were secreted by isolated MDMs. Qiong Xue et al., Sci. Signal. 2015;8:ra59 Copyright © 2015, American Association for the Advancement of Science