MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.

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MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. A and B, TLR4 protein and mRNA expression in doxycycline-treated PC/BRAFV600E cells in the presence of the chemical inhibitors PLX4032 or U0126. Fold change indicates relative TLR4 abundance. *, P < 0.05 and **, P < 0.01 versus vehicle-treated cells; #, P < 0.05 versus same condition in the absence of inhibitor (one-way ANOVA, Newman–Keuls test). C and D, TLR4 protein and mRNA expression in BCPAP cells treated in the presence of the chemical inhibitors PLX4032 or U0126. Fold change indicates relative TLR4 abundance. *, P < 0.05 and **, P < 0.01 versus. vehicle-treated cells (one-way ANOVA, Newman–Keuls test). Victoria Peyret et al. Mol Cancer Res 2018;16:833-845 ©2018 by American Association for Cancer Research