Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence Marit Westman, MD, Christian Lupinek,

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Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence Marit Westman, MD, Christian Lupinek, MD, Jean Bousquet, MD, PhD, Niklas Andersson, MSc, Sandra Pahr, MSc, Alexandra Baar, PhD, Anna Bergström, PhD, Mats Holmström, MD, PhD, Pär Stjärne, MD, PhD, Karin C. Lødrup Carlsen, MD, PhD, Kaj-Håkon Carlsen, MD, PhD, Josep M. Antó, MD, PhD, Rudolf Valenta, MD, PhD, Marianne van Hage, MD, PhD, Magnus Wickman, MD, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 5, Pages 1199-1206.e11 (May 2015) DOI: 10.1016/j.jaci.2014.10.042 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Prevalence of IgE reactivity to PR-10 proteins in the population (≥0.3 ISU-E). B, Specific IgE levels to the different PR-10 proteins among sensitized children (≥0.3 ISU-E), where boxes show the median levels and 25th and 75th percentiles at 4, 8, and 16 years of age, respectively. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Number of children with IgE-reactivity to the different PR-10 proteins (left column) and percentages with additional IgE-reactivity to other PR-10 proteins. Green, High degree of IgE cross reactivity; Red, low degree of IgE cross reactivity. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Proportional Venn diagram of numbers of children who reported symptoms after exposure to birch pollen from the upper and lower airways, respectively, and IgE reactivity to Bet v 1 at 4 (n = 764), 8 (n = 763), and 16 (n = 686) years of age. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Probabilities for incident or persistent ARbp from 4 to 16 years of age in relation to Bet v 1–specific IgE levels (ISU-E) at 4 and 8 years of age, respectively. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Bet v 1–specific IgE levels (ISU-E) at age 4 years among children with mild ARbp compared with those with moderate/severe ARbp at 16 years of age, with box plots showing median levels and 25th and 75th percentiles. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flow chart of the study. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Cross-sectional probabilities to report ARbp at 4, 8, and 16 years of age in relation to levels of specific IgE to birch (measured with ImmunoCAP) among all children in the BAMSE cohort, the 1699 children with blood samples from all 3 time points, and the study population. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Correlation between Bet v 1–specific IgE levels (ISU-E) and numbers of other IgE-reactive PR-10 proteins. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Cross-sectional probabilities to report ARbp in relation to Bet v 1–specific IgE levels (ISU-E) at 4, 8, and 16 years of age. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Cross-sectional probabilities to report symptoms of OAS to any food item in relation to Bet v 1–specific IgE levels or specific food items in relation to levels of IgE specific for the corresponding PR-10 protein at 16 years of age. Journal of Allergy and Clinical Immunology 2015 135, 1199-1206.e11DOI: (10.1016/j.jaci.2014.10.042) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions