Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam A. Chauzy, J. Buyck, B.L.M. de Jonge,

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Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam A. Chauzy, J. Buyck, B.L.M. de Jonge, S. Marchand, N. Grégoire, W. Couet Clinical Microbiology and Infection Volume 25, Issue 4, Pages 515.e1-515.e4 (April 2019) DOI: 10.1016/j.cmi.2018.11.025 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Aztreonam MICs versus avibactam concentrations (mg/L) for 12 Enterobacteriaceae isolates. The circles represent the aztreonam MICs determined during one checkerboard experiment and the solid lines the individual aztreonam MICs predicted by the Emax model with baseline effect. Clinical Microbiology and Infection 2019 25, 515.e1-515.e4DOI: (10.1016/j.cmi.2018.11.025) Copyright © 2018 The Authors Terms and Conditions