Effect of dietary feeding of silibinin on DU145 tumor xenograft growth in athymic male nude mice. Effect of dietary feeding of silibinin on DU145 tumor.

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Effect of dietary feeding of silibinin on DU145 tumor xenograft growth in athymic male nude mice. Effect of dietary feeding of silibinin on DU145 tumor xenograft growth in athymic male nude mice. Approximately 2 million DU145 cells were s.c. injected in the right flank of each mouse to initiate ectopic prostate tumor growth as described in “Materials and Methods.” A, dietary feeding of silibinin started after 24 h of tumor cells injection; B, dietary feeding of silibinin started before and after tumor cell injection. Mice were fed ad libitum with AIN-93M purified diet in three different groups as: group I, control diet; group II, 0.05% silibinin in diet; and group III, 0.1% silibinin in diet, for 60 days. Once tumor xenografts started growing, their sizes were measured twice weekly in two dimensions, throughout the study. The tumor volume was calculated by the formula: 0.5236 L1(L2)2, where L1 is long diameter and L2 is the short diameter. Tumor volume (mm3) is represented as mean of 8–10 mice in each group. C, effect on wet weight of the tumor. At the termination of the study, tumors were excised from each mouse in different groups and weighed. Wet weight of tumors is represented as mean of 8–10 tumors from individual mouse in each group. SB, silibinin; ∗, P < 0.05; #, P < 0.01; †, P < 0.001 at the termination of the experiments; bars, ± SE. Rana P. Singh et al. Cancer Res 2002;62:3063-3069 ©2002 by American Association for Cancer Research