Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages.

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Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages. Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages. A, frozen sections of LL2 tumors from FAP/EGFP BAC Tg mice in which FAP+ cells are identified by native EGFP fluorescence (green) were also stained with DAPI (blue) and antibodies specific for F4/80 (white) and HO-1 (red). B, randomly selected HO-1+ cells across multiple sections and fields were evaluated in three separate LL2 tumors for coexpression of FAP/EGFP and F4/80 (>300 total HO-1+ events were characterized). C, relative HO-1 mRNA expression in subpopulations of FACS-sorted tumoral populations from an LL2/OVA tumor. James N. Arnold et al. Cancer Immunol Res 2014;2:121-126 ©2014 by American Association for Cancer Research