Overview of the strength of evidence of non-pharmacological and pharmacological interventions compared with inactive interventions for the treatment of adult major depressive disorder. Overview of the strength of evidence of non-pharmacological and pharmacological interventions compared with inactive interventions for the treatment of adult major depressive disorder. CBT, cognitive behavioural therapy; SAMe, S-adenosyl-L-methionine; SGA, second-generation antidepressants; SMD, standardised mean difference; TCA, tricyclic antidepressants. Gerald Gartlehner et al. BMJ Open 2017;7:e014912 ©2017 by British Medical Journal Publishing Group