Pdcd4 expression inhibits AP-1 transactivation.

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Pdcd4 expression inhibits AP-1 transactivation. Pdcd4 expression inhibits AP-1 transactivation. Wild-type, Pdcd4-C1, and Pdcd4-G6 mice were bred to AP-1 luciferase reporter mice. Primary keratinocyte cultures were treated with the indicated TPA dose (or 0.1% DMSO) for 13 hours. AP-1 activity refers to luciferase activity per microgram of DNA. Pdcd4 expression was inhibited (46%) both the basal and TPA-induced AP-1 activity in either Pdcd4-C1 or Pdcd4-G6 transgenic cells compared with wild-type cells. *Statistical significance compared with wild-type DMSO alone (P < 0.05). **Statistical significance compared with wild-type respective TPA treatment (P < 0.01). Data are representative of three independent experiments. Aaron P. Jansen et al. Cancer Res 2005;65:6034-6041 ©2005 by American Association for Cancer Research