PVT1 facilitated gastric cancer progression in a FOXM1-mediated manner

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Presentation transcript:

PVT1 facilitated gastric cancer progression in a FOXM1-mediated manner. PVT1 facilitated gastric cancer progression in a FOXM1-mediated manner. A, CCK-8 results showed that knockdown of FOXM1 partially attenuated the enhanced cell proliferation induced by overexpression of PVT1 in AGS and MGC803 cells. *, P < 0.01. B, Representative images (left) and the number of migratory cells (right) per high-power field showed that knockdown of FOXM1 partially attenuated the enhanced migratory ability of AGC and MGC803 cells promoted by PVT1 upregulation. *, P < 0.01. C, Representative images (left) and the number of invading cells (right) per high-power field showed that knockdown of FOXM1 partially attenuated the enhanced invasiveness of AGC and HGC27 cells promoted by PVT1 upregulation. *, P < 0.01. D, Nude mouse xenograft model showed that knockdown of FOXM1 reduced the enhanced volume and weight of tumors by overexpression of PVT1 compared with overexpression of PVT1 only. *, P < 0.01. Mi-die Xu et al. Clin Cancer Res 2017;23:2071-2080 ©2017 by American Association for Cancer Research