A and B, two blocks from the original specimen used for TMA demonstrated areas with varying patterns of ALK rearrangement and KRAS mutation status. A and.

Slides:

Advertisements

Similar presentations

Advertisements

Mrs. Smith’s 7th Grade Reading Blue Class Mrs. Smith’s 7th Grade Reading Blue Class Mrs. Smith’s 7th Grade Reading Blue Class.

Intraosseous Inflammatory Myofibroblastic Tumor of the Twelfth Thoracic Vertebra by Mazda Farshad, Beata Bode, and Kan Min JBJS Case Connect Volume 3(2):e46.

CYB561 mutations. CYB561 mutations. The upper part shows the structure of the CYB561 gene, with the positions of the identified mutations indicated. Gray.

Rearrangements of Gene A and Gene B

Fusion genes in cord blood

Serial imaging while on immunosuppressive therapy (two subjects).

Altered interferon signaling with JAK1 loss-of-function mutation in M431 and interferon gamma-inducible PD-L1 expression by 48 melanoma cell lines. Altered.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

A, representative gross feature of a gastric cancer (arrows), an ulceroinfiltrative mass in the antral mucosa, arising in Pdx-1-Cre;Smad4F/F;Trp53F/F;Cdh1F/+

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

A. glioblastoma with high (+++) KIT protein expression.

ALK and NRG1 Fusions Coexist in a Patient with Signet Ring Cell Lung Adenocarcinoma Lucia Anna Muscarella, PhD, Domenico Trombetta, PhD, Federico Pio.

What Color is it?.

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

Bar plot representation of the transcriptomic changes in Δsaci_ptp and Δsaci_pp2a. Bar plot representation of the transcriptomic changes in Δsaci_ptp and.

BDNF expression in the cerebellum and brain stem region.

Identification and characterization of a novel KRAS rearrangement in metastatic prostate cancer. Identification and characterization of a novel KRAS rearrangement.

Identification of the CD74–NRG1 fusion gene.

Effect of cxcr3.2 mutation on dissemination of local mycobacterial infection within 24 hpi. Effect of cxcr3.2 mutation on dissemination of local mycobacterial.

Clinical Implications of Variant ALK FISH Rearrangement Patterns

SIRT1 is downregulated in human gastric cancer (GC).

Activating mutation of Ras is associated with CDCP1 expression in NSCLC. A, NSCLC cell lines with Ras + B-Raf mutations and wild-type Ras were examined.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

A, Top inhibitors of Ba/F3 transformed with CD74–ROS1, color coded by clinical development status: FDA-approved (green), phase III (yellow), phase II (blue),

CDCP1 colocalizes and interacts with MT1-MMP.

Expression profile of RSPO1 and 2 in gastric cancer.

Association between RB pathway alterations and poor prognosis in early-stage lung adenocarcinoma patients. Association between RB pathway alterations and.

Landscape of the TME in gastric cancer and characteristics of TME subtypes. Landscape of the TME in gastric cancer and characteristics of TME subtypes.

DNA recombination at sites of replication damage in BLM-deficient cells. DNA recombination at sites of replication damage in BLM-deficient cells. A. Nucleotide.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

In vivo thrombosis of tumor vasculature.

Rat endometrial hyperplasia (A) has increased glandular crowding, increased glandular size, increased glandular complexity, and increased epithelial nuclear.

Excerpts of identified gene expression profiles.

The truncating mutation c

SAF-1 expression in clinical breast cancer tissues.

A, unsupervised clustering of all BRCA1 (red), BRCA2 (blue), and sporadic (green) breast tumors of our collection using the regions reported as discriminative.

Modeling of EGFR exon 20 insertions using the 3-dimensional structure of the EGFR kinase domain predicts different interactions with the erlotinib-binding.

Positions of the EGFR exon 20 insertions identified over a 3-year period and comparison with the spectrum of EGFR exon 19 and HER2 insertion mutations.

Activation of mTOR signaling (increased phosphorylated S6 ribosomal protein) and loss of inhibition of IRS-1 in human endometrial carcinomas. Activation.

Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium.

MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification.

Lung tumors in KrasLA1 mice are fibrotic.

Comparison of the frequency of nucleotide variation in the mtDNA D-loop region between stomach and other tumor cell lines. Comparison of the frequency.

Two-way, unsupervised hierarchical clustering representing the 60 tumor cell lines (vertical axis) and the analyzed total, phospho- and cleaved proteins.

Dual-color FISH analysis of 16p13

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Representative photograph of somatic mutations detected by PCR-SSCP.

In vivo demonstration of EMT in GFP-tagged tumors.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

The long tail of mutational hotspots in cancer.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Change in FES uptake in the tumor during fulvestrant treatment.

The activity of MRP1-EYFP is analogous to wild-type MRP1.

ROC analysis of MIC-1 and CA19-9.

Progastrin staining in colon adenomas and adenocarcinomas.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

Global mutational landscape of the 170 lung adenocarcinoma patients (discovery cohort). Global mutational landscape of the 170 lung adenocarcinoma patients.

Molecular definitions of lung adenocarcinoma subtypes.

Double knockdown of HER2/EGFR abolishes HPSE nucleolar localization in 231BR3 cells. Double knockdown of HER2/EGFR abolishes HPSE nucleolar localization.

Predicted pathogenic BRCA1 amino acid substitutions are confined to the evolutionarily conserved N- and C-terminal domains. Predicted pathogenic BRCA1.

Representative images for different populations of detected cells in prostate cancer patients and five rounds of FISH in a CTC. A, Immunofluorescence image.

Venn diagram showing the overlap of PD-L1 overexpression, MSI-NGS–high, and TML-high in all gastrointestinal tumors, with all three markers tested (N =

The ovarian cancer cell lines modestly recapitulate the spectrum of mutations found in primary ovarian tumors. The ovarian cancer cell lines modestly recapitulate.

Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.

Expression of XCR1 in EOC cell lines.

Driver pathways and key genes in OSCC

Fig. 2 Spatial distribution of five city groups.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

A and B, two blocks from the original specimen used for TMA demonstrated areas with varying patterns of ALK rearrangement and KRAS mutation status. A and B, two blocks from the original specimen used for TMA demonstrated areas with varying patterns of ALK rearrangement and KRAS mutation status. Red-circled areas indicate ALK rearranged and mutated KRAS (ALK+/KRAS+). Blue-circled areas indicate ALK wild-type and KRAS mutated (ALK−/KRAS+). Green-circled areas indicated ALK rearranged and KRAS wild-type (ALK+/KRAS−). Black areas indicate wild-type for both alterations (ALK−/KRAS−). C and D, higher magnification of the regions indicated in E by yellow arrows demonstrates that some regions are best classified as high-grade dysplasia. FISH analysis in region C was positive for ALK rearrangement and FISH analysis in region D was negative for ALK rearrangement (FISH images not shown). Dara L. Aisner et al. Mol Cancer Res 2014;12:111-118 ©2014 by American Association for Cancer Research