Hippo-based model. Hippo-based model. Arrows point out the direction of signaling: in orange, the YAP signaling effects on p73 driven by c-Abl, in blue.

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Hippo-based model. Hippo-based model. Arrows point out the direction of signaling: in orange, the YAP signaling effects on p73 driven by c-Abl, in blue the YAP signaling effects on the transcription factor RUNX1 driven by c-Src. In pink, the involvement of mir-211 in stress-activated protein kinase (SAPK)/c-jun-NH2-kinase (JNK) and SMAD signaling, as well as in epithelial–mesenchymal transition (EMT) is shown. Signaling pathway model made with PathVisio v2.0 (37). Giulia Federici et al. Mol Cancer Res 2013;11:676-685 ©2013 by American Association for Cancer Research