Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma Tomoharu Yoshiya, MD, Takahiro Mimae, MD, PhD, Yasuhiro.

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Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma Tomoharu Yoshiya, MD, Takahiro Mimae, MD, PhD, Yasuhiro Tsutani, MD, PhD, Norifumi Tsubokawa, MD, Shinsuke Sasada, MD, PhD, Yoshihiro Miyata, MD, PhD, Kei Kushitani, MD, PhD, Yukio Takeshima, MD, PhD, Shuji Murakami, MD, PhD, Hiroyuki Ito, MD, PhD, Haruhiko Nakayama, MD, PhD, Morihito Okada, MD, PhD The Annals of Thoracic Surgery Volume 102, Issue 5, Pages 1668-1673 (November 2016) DOI: 10.1016/j.athoracsur.2016.04.087 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Three-year overall and recurrence-free survival rates of patients with different tumor subtypes. (A) Three-year overall survival rates were 98%, 97%, and 85% for patients with lepidic predominant invasive adenocarcinoma (LPA [solid line]), papillary and acinar predominant invasive adenocarcinoma (PA [dashed line]), and solid and micropapillary predominant invasive adenocarcinoma (SM [dotted line]) tumors, respectively. Survival rates significantly differed among groups (LPA versus PA, p = 0.099; LPA versus SM, p < 0.001; PA versus SM, p = 0.032). (B) Three-year recurrence-free survival rates were 98%, 88%, and 64% for patients with LPA (solid line), PA (dashed line), and SM (dotted line) tumors, respectively. Survival rates significantly differed among groups (LPA versus PA, p = 0.014; LPA versus SM, p < 0.001; PA versus SM, p < 0.001). The Annals of Thoracic Surgery 2016 102, 1668-1673DOI: (10.1016/j.athoracsur.2016.04.087) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions