Fig. 2 Dynamics of Nef-stop repair and predictors of viral set-point.

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Fig. 2 Dynamics of Nef-stop repair and predictors of viral set-point. Dynamics of Nef-stop repair and predictors of viral set-point. (A and B) Correlations between the percentage of virus in plasma restored to Nef-OPEN at week 2 after infection and (A) plasma viral load at week 2and (B) plasma viral load at week 5. (C and D) Correlation between plasma viral load set point (average of week 45 and week 48 after infection) and AUC of log plasma viremia (C) during the first 5 weeks of infection, before ART initiation, or (D) during the first months of ART, prior to antibody infusion. Red dots, control animals; blue dots, α4β7-treated animals. (E) Pie charts summary of the Nef sequencing data. Each slice corresponds to the proportion of viruses in plasmas of animals at weeks 2 and 5 after infection with specific amino acid substitutions at position 97 of Nef, where black indicates Nef-STOP. Animals were ranked from top to bottom in each group on the basis of the amount of Nef-STOP virus. Plasma viral loads throughout the course of the study reveal association between early and long-term viral replication, independent of the treatment received. (F) The log of the geometric means of animals achieving >5 log viremia at set point (black) and of animals achieving <4 log viremia at set point (green) are shown along with the viral kinetics of each subject (solid lines indicate animals from the active group, and dashed lines indicate animals from the control group). M. Di Mascio et al. Science 2019;365:1025-1029 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works