Domain structure of TLR2 (A) and Nod2 (B).

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Domain structure of TLR2 (A) and Nod2 (B). Domain structure of TLR2 (A) and Nod2 (B). Numbers correspond to amino acid residues. A. TLR2 structure (data from references 44 and 118). ECD, extracellular domain; TMD, transmembrane domain; ICD, intracellular domain; TIR, Toll/IL-1 receptor domain. The regions homologous to LRRs are indicated by square boxes, and LRR-like motifs are indicated by boxes with an asterisk. B. Nod2 structure (data from reference 141). CARD, caspase-activating and recruitment domain; NBS, nucleotide binding site and LRR domain. Bénédicte Fournier, and Dana J. Philpott Clin. Microbiol. Rev. 2005; doi:10.1128/CMR.18.3.521-540.2005