CD24 expression. CD24 expression. A, By global gene expression, CD24 is found to be highly upregulated in SEF (80×) and in LGFMS (37×) as compared with.

Slides:

Advertisements

Similar presentations

AF647-RIS is internalized by TAMs in vivo.

Advertisements

Fig. 8. Recurrent copy number amplification of BRD4 gene was observed across common cancers. Recurrent copy number amplification of BRD4 gene was observed.

GM-CSF induces tumor cell EMT and stemness.

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

IL32 prompts cell activation and cancer-related pathways.

Tregs and APC subsets in TDLNs of patients with cervical cancer.

Alterations related to androgen signaling.

Loss of Keap1 contributes to LSCC pathogenesis by activating the NRF2–ROS pathway. Loss of Keap1 contributes to LSCC pathogenesis by activating the NRF2–ROS.

Quantification of MHC-I, β2m, and T-cell subsets.

Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Highly related T9 and T3 sarcoma.

CPI-444 efficacy requires CD8+ T cells and is associated with increased CD73 expression. CPI-444 efficacy requires CD8+ T cells and is associated with.

Dox titration and kinetic analyses of CD19CAR expression upon Dox administration and discontinuation. Dox titration and kinetic analyses of CD19CAR expression.

Derivation of ImSig. Derivation of ImSig. A, An example of a correlation network generated from a tissue data set where nodes represent unique genes and.

Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells.

Identification of a ufo1 Candidate Gene from the Mapping Region.

IL32 is highly expressed in mycosis fungoides lesional skin.

FAK overexpression in invasive human breast cancer and DCIS

FAK overexpression in invasive human colon cancer and colon dysplasia.

Colony-forming capacity of CD34+ cells with and without CLL-1 expression. Colony-forming capacity of CD34+ cells with and without CLL-1 expression. CD34+

Antigen-specific CD8+ T cells express higher levels of PD-1 in animals that received the optimized SSX2 vaccine. Antigen-specific CD8+ T cells express.

Various impediments in the uptake and retention of radiolabeled antibodies in solid tumors and strategies to modulate these biological barriers. Various.

AXL is not expressed in human prostate tumors.

Binding and internalization of bispecific immunotoxins.

Greater induction of apoptosis following EGFR TKI treatment correlates with higher basal BIM expression across a panel of EGFR-mutant lung cancers. Greater.

Relationship between the expression of immune-related genes and burdens of somatic mutation. Relationship between the expression of immune-related genes.

M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. M-Wnt and E-Wnt cells cluster.

Expression of CRC stem cell markers and L1 in CRC cells.

Transcriptional and genomic targets of EN1 in TNBC cells.

EN1-associated chromatin complexes in breast cancer cells.

SAF-1 expression in clinical breast cancer tissues.

ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.

Specific up-regulation and down-regulation of immunomodulatory genes in human breast and colorectal cancers. Specific up-regulation and down-regulation.

Molecular signatures are independent of tumor stage and grade.

5FU-induced specific activation of CD8+ T cells.

Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Transcripts enriched and depleted in NB TICs compared with SKPs.

Expression of S100A11 in bulk pancreatic tissues (pancreatic cancer, n = 22; IPMN, n = 18; nonneoplastic pancreas, n = 22). Expression of S100A11 in bulk.

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination.

Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Circulating leukocytes.

Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and.

Reduced klotho expression in pancreatic cancer.

Phenotypic diversity of individual multiple myeloma clones.

Correlations of the breast cancer hypoxia metagene with Ki67 and the proliferation metagene. Correlations of the breast cancer hypoxia metagene with Ki67.

Intratumoral changes in critical lymphocyte populations and numbers after NKTR-214 treatment. Intratumoral changes in critical lymphocyte populations and.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

Kaplan–Meier curves for RFS and OS by various marker groups.

Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages.

Association of overall survival and PAP-specific (A, B) and PA2024-specific (C, D) CTL activity at week 26 using categorical (tertile) analysis and continuous.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

ROC analysis of MIC-1 and CA19-9.

Specific reaction with MIB1, M30, and CD31 monoclonal antibodies in primary human cervical carcinoma before (A, C, and E) and after (B, D, and F) Tam treatment.

Molecular definitions of lung adenocarcinoma subtypes.

The CCR5+ population of SUM-159 cells is enriched with tumor-initiating cells. The CCR5+ population of SUM-159 cells is enriched with tumor-initiating.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Inhibition of CD20 mRNA expression by ibrutinib correlates with reduced NF-κB activity. Inhibition of CD20 mRNA expression by ibrutinib correlates with.

Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.

Establishment of HeLa/rtTAA/TRE-N1-IC cell line.

Defining the eTME genes.

Expression of chemokine receptors in A-498 cell line.

IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. IL-1β expression is increased in MM cell lines by the co-culture.

Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

CD36 expression in tissue adjacent and distal to the tumor.

EC-derived SP cells are targeted by CD30.CAR T cells.

Coincidence and prognostic significance of PD-1+ and CD103+ cells in HGSC. Serial sections from the 490-case TMA were stained with antibodies to CD103.

Overexpression of sRNA-29 changes the expression of 53 genes across the P. denitrificans genome. Overexpression of sRNA-29 changes the expression of 53.

Transcriptome profiling of PD-L1 antibody–treated macrophages showed inflammatory phenotype, increased survival and proliferation, and decreased apoptosis.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

CD24 expression. CD24 expression. A, By global gene expression, CD24 is found to be highly upregulated in SEF (80×) and in LGFMS (37×) as compared with a set of control tumors (left box plot). In line with that, Tet-On 3G cells expressing the EWSR1-CREB3L1 fusion (E-C Dox cells) and Tet-On 3G cells expressing the FUS-CREB3L2 fusion (F-C Dox cells) also show upregulation of CD24 (125× and 28×, respectively) as compared with the No Dox counterpart and the controls (right box plot). B, CD24 FACS on Tet-On 3G cells expressing EWSR1-CREB3L1 (E-C Dox) and FUS-CREB3L2 (F-C Dox) was well in line with the RNA-seq results visualized in the box plots above. Cell surface CD24 expression was 42× higher, and total CD24 expression was 50× higher in E-C Dox (red line) than in E-C No Dox (blue line) in the cell clone illustrated. C, IHC showed cytoplasmic and membranous staining of CD24 in cases 5 (left) and 6A (right). Elsa Arbajian et al. Clin Cancer Res 2017;23:7426-7434 ©2017 by American Association for Cancer Research