Volume 63, Issue 6, Pages (September 2016)

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Volume 63, Issue 6, Pages 913-915 (September 2016) Restraining the Divider: A Drp1-Phospholipid Interaction Inhibits Drp1 Activity and Shifts the Balance from Mitochondrial Fission to Fusion David F. Kashatus Molecular Cell Volume 63, Issue 6, Pages 913-915 (September 2016) DOI: 10.1016/j.molcel.2016.08.033 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of the Regulation of Mitochondrial Dynamics by Interactions between Dynamin-Related GTPases and the Mitochondrial Outer Membrane The fission GTPase Drp1 can interact with both cardiolipin (CL), which promotes fission activity, and phosphatidic acid (PA), which inhibits fission and promotes fusion. In addition, Drp1 can recruit mitoPLD, which converts CL to PA and thus shifts the balance from fission to fusion. Molecular Cell 2016 63, 913-915DOI: (10.1016/j.molcel.2016.08.033) Copyright © 2016 Elsevier Inc. Terms and Conditions