UNC drives MYC protein loss.

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UNC10112785 drives MYC protein loss. UNC10112785 drives MYC protein loss. (A) Chemical structure of UNC10112785. The red circle indicates the position at which different analogs were synthesized. (B) GPS-MYC cells were treated with 20 μM UNC10112785 for 6 hours, and EGFP and DsRed intensity was measured by flow cytometry. Data from the GPS-MYC screen. (C) GPS-MYC cells were treated with UNC10112785 for 6 hours, and EGFP-MYC and MYC abundance was measured by immunoblotting. (D) PDAC cells were treated with UNC10112785, and MYC protein abundance was measured by immunoblot. (E) Kinase selectivity of UNC10112785 as described previously (30). (F) MIA PaCa-2 cells were treated for 6 hours with the indicated compounds, and MYC protein abundance was measured by immunoblot. All data are representative of at least three independent experiments. Devon R. Blake et al., Sci. Signal. 2019;12:eaav7259 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works