Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. A,

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Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. A, NB4 cells were treated with DMSO (control) or atorvastatin for the indicated times, at the indicated concentrations. The induction of apoptosis was evaluated by flow cytometry using Annexin V/propidium iodide staining. Columns, mean % early and late apoptotic cells of two independent experiments; bars, SE. B to D, NB4 (B), NB4 007/6 (C), or NB4 306 (D) cells were incubated for 48 h in the absence or presence of DMSO (control), atorvastatin (2 μmol/L), or fluvastatin (2 μmol/L). The induction of apoptosis was evaluated by flow cytometry using Annexin V/propidium iodide staining. Columns, mean % early and late apoptotic cells four (B), three (C), and two experiments (D); bars, SE. For the experiments in (B), paired two-tailed t test analysis showed a two-tailed P = 0.00257 for atorvastatin versus DMSO and a two-tailed P = 0.00007 for fluvastatin versus DMSO. Antonella Sassano et al. Cancer Res 2007;67:4524-4532 ©2007 by American Association for Cancer Research