Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Slides:



Advertisements
Similar presentations
Anti-CD40 and CpG induce activation of T cells in draining lymph nodes
Advertisements

Detection of CD38+IgG1+ memory B cells adjacent to contracted GCs
Type 17 immunity is increased in STAT1−/− mice.
Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.
CD1dhiCD5+ B cells are expanded in pancreatic neoplasia and are functionally important for sustaining growth of KrasG12D-PDEC in vivo. CD1dhiCD5+ B cells.
Frequencies of immune cell types show much stronger variations between tumor types in the tumor infiltrate compared with the spleen and tumor-draining.
B-cell differentiation associates with down-regulation of vimentin expression. B-cell differentiation associates with down-regulation of vimentin expression.
Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.
Depo-Provera altered the expression of cell surface markers associated with HIV susceptibility. Depo-Provera altered the expression of cell surface markers.
Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.
Immunologic responses after the MN-mediated cancer immunotherapy.
FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.
DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.
Volume 21, Issue 7, Pages (November 2017)
PD‐L1 silencing in antigen presenting DCs results in hyperactivated pro‐inflammatory TCRhigh CD8+ T cells. PD‐L1 silencing in antigen presenting DCs results.
Administration of pIL2 and pgDE7 induces higher activation of E7-specific Tem CD8+ T cells. Administration of pIL2 and pgDE7 induces higher activation.
A CD4 Domain 1 CC′ Loop Peptide Analogue Enhances Engraftment in a Murine Model of Bone Marrow Transplantation with Sublethal Conditioning  Gabor Varadi,
STAT3 regulates IgE class switching in a Th2-type response.
CD160−/− mice have impaired clearance of oral L
Conditional deletion of MHC II on B cells does not regulate atherosclerotic plaque development in Ldlr−/− mice. Conditional deletion of MHC II on B cells.
Conditional expression of MHC II on B cells does not regulation atherosclerotic plaque development in Ldlr−/− mice. Conditional expression of MHC II on.
Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.
STAT3 regulates GC and plasma cell IgE class switching in B cells.
Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.
Loss of DGKζ and Cbl-b results in a greater percentage of splenic CD8+ T cells with an activated phenotype. Loss of DGKζ and Cbl-b results in a greater.
Bindiya Patel et al. BTS 2018;j.jacbts
CpG-Induced Myeloid CD11b+Gr-1+ Cells Efficiently Suppress T Cell–Mediated Immunoreactivity and Graft-Versus-Host Disease in a Murine Model of Allogeneic.
CXCR5 expression accelerates Eμ-Tcl1 leukemogenesis and is indispensable for tumor cell recruitment to lymphoid B-cell follicles. CXCR5 expression accelerates.
Volume 43, Issue 5, Pages (November 2015)
Etifoxine modulation of T‐cell activity during EAE
Fig. 5 Extended local release of R848 increases the number of innate and adaptive antitumor immune cells and cytokines. Extended local release of R848.
VH usage of cross-reactive B cells induced by H5N1 or H7N9 vaccination
Development of human T-cell subsets in NSG hL-7xhIL-15 humanized mice.
Transfer of NRP1-expressing bone marrow improves the metabolic phenotype of LysM-Cre-Nrp1fl/fl mice. Transfer of NRP1-expressing bone marrow improves the.
Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.
Volume 50, Issue 2, Pages e4 (February 2019)
Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.
Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.
Loss of Setdb1 in early B cells leads to impaired B cell development.
TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.
PD-L1 selectively marks circulating NCMs.
Blocking the PD-1 pathway in CD28−/− NOD
Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and increased T-cell activation. Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and.
Comparison of conventional NSG and hIL-7 expressing NSG humanized mice
SYK activity is required for anti-IgM–induced CD86 expression.
B cell development in wild-type and Syk-AQL mice.
CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.
LG NK cells appear to be conventional in phenotype.
Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.
Major hematopoietic cell populations in NOD mice are not affected by c-Rel deficiency. Major hematopoietic cell populations in NOD mice are not affected.
The number of islet antigen–specific T cells is reduced in CT-treated RIP-LCMV-GP mice. The number of islet antigen–specific T cells is reduced in CT-treated.
Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.
Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.
Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.
Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.
Reduced tumor growth in CCR5-deficient mice is associated with perturbed killing ability of Treg cells. Reduced tumor growth in CCR5-deficient mice is.
GC reaction is impaired in NOTCH2 knock-in mice.
Fig. 1 Bcl11b removal in Treg cells results in early death of mice and increased CD4+ and CD8+ T cell activation. Bcl11b removal in Treg cells results.
Deletion of Tgfbr2 in myeloid cells elevated IFN-γ production in CD8+ T cells, and systemic IFN-γ neutralization diminished metastasis inhibition in Tgfbr2MyeKO.
B- and T-cell activity induced by immunization.
Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.
Mice with a B cell–specific loss of Ets1 have reduced marginal zone B cells and increased ASCs. (A) Flow cytometry analysis of CD21 versus CD23 in gated.
Local proliferation of infiltrating circulating memory T cells.
miR-146a is highly expressed selectively on γδ27− T cells.
Loss of polarity gene Dlg1 leads to an expansion of C'-1 stage cells during pre-B cell differentiation. Loss of polarity gene Dlg1 leads to an expansion.
IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.
Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.
E2 induces IL-17–producing γδ+ T cells in the FGT
Varying the MHC-I affinity, TCR affinity or antigen dose alters the phenotype of CD8 T cells ex vivo. Varying the MHC-I affinity, TCR affinity or antigen.
Bb monocolonization enhances Treg population in the cLP.
Presentation transcript:

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. (A) Flow cytometry analysis of PDL2 versus CD80 in gated live B220+ B cells showing that Ets1−/− and CD19-Cre Ets1fl/fl mice have increased percentages of B cells with a memory phenotype (PDL2+CD80+). (B) Quantification of the percentages of memory B cells in spleen and lymph nodes of the various strains of mice (n = 6 Ets1+/+, 6 Ets1−/−, 9 CD19-Cre Ets1+/+, and 6 CD19-Cre Ets1fl/fl mice). (C) Flow cytometry analysis of B220 versus IgG1 in gated live splenocytes showing that Ets1−/− mice, but not CD19-Cre Ets1fl/fl mice, have increased percentages of IgG1+ B cells. (D) Quantification of the percentages of IgG1+ B cells in the spleen and lymph nodes of the various strains of mice (n = 21 Ets1+/+, 17 Ets1−/−, 11 CD19-Cre Ets1+/+, and 12 CD19-Cre Ets1fl/fl mice). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, not significant. Alex Sunshine et al. ImmunoHorizons 2019;3:331-340 Copyright © 2019 The Authors