Γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. γ-TmT reduces serum E2 levels and induces estrogen-metabolizing.

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γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. A, analysis of E2 levels in ACI rat serum at 6, 18, and 31 weeks (n = 6/group for 6, 18 weeks; n = 9/group for 31 weeks). B, qPCR analysis of CYP1A1 and CYP1B1 mRNA expression in the mammary glands (6, 18 weeks), tumors (31 weeks), and liver (31 weeks) of ACI rats (n = 6–8/group). Statistical significance: *, P < 0.05; **, P < 0.01; ***, P < 0.001. C, Western blot analysis of CYP1A1 and CYP1B1 in the mammary tumors of ACI rats at 31 weeks (n = 3/group). Soumyasri Das Gupta et al. Cancer Prev Res 2015;8:807-816 ©2015 by American Association for Cancer Research