Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R1507 1 mg/kg (n.

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Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R1507 1 mg/kg (n = 6), 3 mg/kg (n = 6), or 9 mg/kg (n = 23). Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R1507 1 mg/kg (n = 6), 3 mg/kg (n = 6), or 9 mg/kg (n = 23). Solid lines, R1507 concentrations; dotted lines, % change in IGF-I level. Razelle Kurzrock et al. Clin Cancer Res 2010;16:2458-2465 ©2010 by American Association for Cancer Research