DTH responses to multiple components of the ID93 fusion protein.

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DTH responses to multiple components of the ID93 fusion protein. DTH responses to multiple components of the ID93 fusion protein. (A) PBS; (B) PPD; (C) ID93; (D) Rv1813; (E) Rv3620; (F) Rv2608; (G) Rv3619. Guinea pigs (n = 5/group) were immunized i.m. three times, 3 weeks apart, with 1 μg of ID93 and 5 μg of GLA-SE. DTH responses were determined 2 weeks after the third immunization with ID93/GLA-SE. PPD (Tubersol, 5 TU), ID93 (1 μg/100 μl), Rv1813 (1 μg/100 μl), Rv3620 (1 μg/100 μl), Rv2608 (1 μg/100 μl), or Rv3619 (1 μg/100 μl) were delivered i.d. on the back of the guinea pigs as skin test antigens. DTH responses were measured 48 h after injection. Dot plots of individual guinea pig DTH responses are indicated with either circles (PBS), squares (BCG), or triangles (ID93/GLA-SE). The results are represented by the diameter of induration in mm (the line represents the mean response). The asterisk represents statistical significance compared to PBS (*, P < 0.05). Susan L. Baldwin et al. Clin. Vaccine Immunol. 2014; doi:10.1128/CVI.00372-14