Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole.

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Presentation transcript:

Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole for the clinical isolate; ▪, effective daily dose of fluconazole. Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole for the clinical isolate; ▪, effective daily dose of fluconazole. MICs are represented on the secondary y axis, in logarithmic scale. Boxes above the graph represent genetic changes identified at each stage. Based on data from Redding et al. (78), White (108, 109), and White et al. (110). (Reprinted from reference 23 with permission.)‏ M. A. Pfaller et al. Clin. Microbiol. Rev. 2006; doi:10.1128/CMR.19.2.435-447.2006