Growth inhibition of HNSCC cells in vitro with curcumin

Slides:

Advertisements

Similar presentations

Copyright © 2009 American Medical Association. All rights reserved.

Advertisements

Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2007 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2006 American Medical Association. All rights reserved.

Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A2 David Mauchley, MD, Xianzhong Meng, MD, PhD, Thomas.

RGFP-966 decreases HDAC3 activity and is not cytotoxic.

Contrast medium-induced nephropathy: The pathophysiology

Fig. 5. Silencing of TAB2 mimics the effects of miR-155-5p on BSMCs

IL-6 signaling affects response to erlotinib in head and neck (HNSCC) cells. IL-6 signaling affects response to erlotinib in head and neck (HNSCC) cells.

A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P =

Fig. 1. Treatment with IL-13 induces proliferation and migration of BSMCs. (A) MTT assay was performed to evaluate the effects of IL-13 on the proliferation.

Cell viability assay and expression of COX protein.

Induction of apoptosis by NS398.

Evaluation of top candidate clones for selective killing in bispecific antibody format. Evaluation of top candidate clones for selective killing in bispecific.

EGCG inhibits cell survival and growth of EFT cell lines but not of HBMECs. A, dose-responsive curves of fractional survival of EFT cells (TC32 and TC71)

A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control.

Treatment effects of fenretinide (4-HPR, 5 μmol/L), 2-ME (2

Suppression of melanoma cell proliferation in response to kinase inhibitors. Suppression of melanoma cell proliferation in response to kinase inhibitors.

In vitro binding and specificity of OTL78.

In vitro invasion assays were done in the Chemicon invasion chamber containing extracellular matrix. In vitro invasion assays were done in the Chemicon.

Primary human airway smooth muscle cells were stimulated with different concentrations of a, e) 18 mg·mL−1 nicotine tobacco-flavoured e-cigarette vapour.

Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis. Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis.

Inhibitory effects of nobiletin and resveratrol on LPS/IFN-γ-induced NO generation in RAW cells. Inhibitory effects of nobiletin and resveratrol.

Radiosensitization by combined Wee1 and PARP inhibition.

Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c

Matriptase-2 inhibited breast tumor development in vivo.

A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.

IL-13Rα2 promotes cell survival and proliferation.

Bcl-2 and caspase inhibition fails to inhibit BAMLET-induced cytotoxicity in MCF-7 cells. Bcl-2 and caspase inhibition fails to inhibit BAMLET-induced.

The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A,

Specific cytotoxicity of DTEGF13.

Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.

LY induces cytotoxicity in hMECs via inhibition of Akt/p70S6K kinase activities. LY induces cytotoxicity in hMECs via inhibition of Akt/p70S6K.

Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. Induction of cytotoxic activity in humanized SCC3.

Antitumor effects of celastrol in vitro and in vivo.

Alkaline Comet assay showing DNA break formation after 6-TG treatment, implying more SSBs generated in MMR+ cells. Alkaline Comet assay showing DNA break.

Time course of a G2-M arrest in response to 6-TG compared with IR and VP-16, showing that 6-TG induced a delayed G2-M arrest in MMR+ cells. Time course.

Targeting HR via CDK inhibition resensitizes recurrent cultures to temozolomide (TMZ). Targeting HR via CDK inhibition resensitizes recurrent cultures.

Tipifarnib and bortezomib are synergistic in cytotoxicity assays

Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma cells. Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma.

Synergistic cytotoxicity of 17AAG and TNF treatment in human lung cancer cell lines. Synergistic cytotoxicity of 17AAG and TNF treatment in human lung.

In vitro time course assays for four renal selective compounds.

Immunologic and pharmacokinetic studies.

Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. LNCaP,

A protracted ketogenic diet increases radiation response in H292 lung cancer xenografts given conventional fractionated radiation. A protracted ketogenic.

PC-3 (A) and DU-145 (B) cell survival analysis by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay following 48 h treatment with 0 μmol/L.

NKT cell recognition of CD1d1 molecules is inhibited by treatment with ascites. NKT cell recognition of CD1d1 molecules is inhibited by treatment with.

6-TG dose and time relationships for DSB formation using PFGE, demonstrating that the formation of DSBs in both MMR+ M4 and MMR− V2 cells is dose dependent.

Identification of compounds that enhance TMZ cytotoxicity in melanoma cells by screening the Spectrum Collection library. Identification of compounds that.

The effects of 5α-dihydrotestosterone and growth factors (insulin-like growth factor I and epidermal growth factor) on LNCaP cell proliferation. The effects.

Pdcd4 expression inhibits AP-1 transactivation.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

VEGF165 stimulates migration of HMVECs

Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions. Effect of silencing β-catenin.

RhuαVEGF and rhuαVEGF/paclitaxel mediated growth inhibition in an androgen-independent prostate cancer xenograft model. rhuαVEGF and rhuαVEGF/paclitaxel.

Lapatinib cooperates with PLX4032 to inhibit BRAF-mutant thyroid cancer cell growth. Lapatinib cooperates with PLX4032 to inhibit BRAF-mutant thyroid cancer.

A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. A, DMA and Ral significantly inhibit estrone methyl ether.

AKT activation in HCC2429 is SRC- but not Notch-dependent.

Interaction of NHEJ and HR pathways in PCO cultures.

In silico, in vitro, and pharmacokinetic evaluation of the synthesized SANs. A, docking for sunitinib and SAN1–5 with estimated inhibition constants (Ki.

PDL192 and inhibit the growth of xenograft tumors.

BEZ235 induces accelerated senescence after radiation (IR) in vitro.

Flavopiridol inhibits rhabdoid cell survival and induces cell cycle arrest and apoptosis. Flavopiridol inhibits rhabdoid cell survival and induces cell.

BME treatment increases cytotoxic activity of NK3

Curcumin decreases viability and proliferation of Bcr-Abl-expressing cells. Curcumin decreases viability and proliferation of Bcr-Abl-expressing cells.

A, Pharmacologically inhibiting protein tyrosine kinases significantly reduces the viability of ATRT cell lines as compared with control HEK 293 cells.

Afatinib rapidly destabilizes endogenous TRIB2 and specifically induces caspase 3 cleavage and U937 cytotoxicity. Afatinib rapidly destabilizes endogenous.

I3C reduces the level of Cdc25A protein in breast cancer cells.

Expression of the angiogenic phenotype in the 4-NQO mouse model of HNSCC. A, tissue sections containing areas of normal, hyperkeratosis, dysplasia, and.

Presentation transcript:

Growth inhibition of HNSCC cells in vitro with curcumin Growth inhibition of HNSCC cells in vitro with curcumin. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were done on CCL23 (A), CAL27 (B), and UM-SCC1 (C) cells following treatment with increasing doses of curcumin dissolved in DMSO. DM... Growth inhibition of HNSCC cells in vitro with curcumin. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were done on CCL23 (A), CAL27 (B), and UM-SCC1 (C) cells following treatment with increasing doses of curcumin dissolved in DMSO. DMSO alone has some inhibitory effect; however, curcumin has a significantly greater cytotoxic effect in all three cell lines (P < 0.0001). There is near-complete cell death with 150 μmol/L of curcumin in CCL23 and UM-SCC1 cell lines, and a concentration of 400 μmol/L is required to achieve complete cell killing in CAL27 cells. Maria M. LoTempio et al. Clin Cancer Res 2005;11:6994-7002 ©2005 by American Association for Cancer Research